[Home ] [Archive]   [ فارسی ]  
:: Main In Press Current Issue All Issues Search register ::
Main Menu
Home::
Journal Information::
Editorial Board::
Articles archive::
For Authors::
For Reviewers::
Editorial Policy::
Registration::
Contact us::
::
..
Indexing

 

 

 

 

 
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Creative commons

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

..
:: Volume 24, Issue 1 (Spring 2024) ::
J Ardabil Univ Med Sci 2024, 24(1): 107-119 Back to browse issues page
The Comparative Study of Antibacterial Effects of Different Hydroethanolic Extracts of Artemisia Species against Common Bacterial Strains in Nosocomial Infections
Ramin Abiri , Samira Ghasemi , Nastaran Sharei , Masumeh Shahbazi , Ahmad Emami , Mahdi Mojarrab *
Pharmaceutical Sciences Research Center, Research Institute for Health, Kermanshah University of Medical Sciences, Kermanshah, Iran , mmojarrab@kums.ac.ir
Abstract:   (183 Views)
Background: Nosocomial infections are considered as the important parts of the treatment challenges in hospitals. The genus Artemisia is widely distributed in Iran. Their species produce antibacterial, antiviral, and antifungal compounds belonging to different groups including phenols, terpenoids, sterols and polyacetylenes. The purpose of the present study is to investigate the in vitro effects of different hydroethanolic extracts of Artemisia species against bacterial strains in nosocomial infection.
Methods: 12 different extracts, including 50% and 70% hydroethanolic extracts were prepared from the aerial parts of Artemisia ciniformis, A. turanica, A. kopetdaghensis, A. khorasanica, A. vulgaris, and A. sieberi. The winterization of the extracts produced corresponding defatted extracts. The minimum inhibitory concentration (MIC) values of the extracts against the bacterial strains Staphylococcus aureus, Streptococcus pyogenes, Acinetobacter sp., Pseudomonas aeruginosa, Enterococcus faecalis, Staphylococus epidermidis, Micrococcus luteus, Klebsiella  pneumoniae and Escherichia coli were measured using the microdilution broth method. Total phenolic contents were determined by the Folin-Ciocalteu method.
Results: Among the extracts analyzed in this experiment, the lowest MIC value was observed for the 50% hydroethanolic extract of A. turanica (0.25 mg/ml) against S. epidermidis. The largest range of bacterial sensitivity (6 strains) was related to the 50% hydroethanolic extracts of A. turanica (defatted and non-defatted) and A. kopetdaghensis (defatted). The growth of S. epidermidis was inhibited by all of the extracts. The highest total phenolic content and yield of extraction were recorded for 70% hydroethanolic extract of A. sieberi and 50% hydroethanolic extract of A. ciniformis, respectively.
Conclusion: The 50% hydroethanolic extract of A. turanica was superior to the other extracts in terms of the in vitro antibacterial spectrum and selective potency. A. turanica and A. kopetdaghensis are probably suitable choices for further phytochemical and antibacterial investigations.
Article number: 8
Keywords: Artemisia, Anti-bacterial Agents, Nosocomial Infections
Full-Text [PDF 472 kb]   (108 Downloads)    
Type of Study: short communication | Subject: General
Received: 2023/12/18 | Accepted: 2024/03/28 | Published: 2024/08/5
References
1. Sukumaran V, Senanayake S. Bacterial infections of the skin and soft tissues. Aust Prescr. 2016; 39(5): 159-163. [DOI:10.18773/austprescr.2016.058] [PMID] []
2. Breneman DL. Bacterial infections of the skin and soft tissues and their treatment. Curr Opin Infect Dis. 1993; 6 (5): 678-82. [DOI:10.1097/00001432-199310000-00010]
3. Ahameethunisa AR, Hopper W. In vitro antimicrobial activity on clinical microbial strains and antioxidant properties of Artemisia parviflora. Ann clin microbiol antimicrob. 2012; 11(1):30. [DOI:10.1186/1476-0711-11-30] [PMID] []
4. Hancock RE. Mechanisms of action of newer antibiotics for Gram-positive pathogens. Lancet Infect Dis. 2005; 5(4): 209-18. [DOI:10.1016/S1473-3099(05)70051-7] [PMID]
5. Juteau F, Masotti V, Bessiere JM, Dherbomez M, Viano J. Antibacterial and antioxidant activities of Artemisia annua essential oil. Fitoterapia. 2002; 73(6): 532-535. [DOI:10.1016/S0367-326X(02)00175-2] [PMID]
6. Rawani A, Pal S, Chandra G. Evaluation of antimicrobial properties of four plant extracts against human pathogens. Asian Pac J Trop Biomed. 2011; 1(1): S71-S5. [DOI:10.1016/S2221-1691(11)60127-5]
7. Hussain A, Hayat MQ, Sahreen S, Ain QU, Bokhari SA. Pharmacological promises of genus Artemisia (Asteraceae): a review. Proceedings of the Pakistan academy of sciences: B Life Environ Sci. 2017; 54(4): 265-87.
8. Baradaran M, Jalali A. A review on Antibacterial effects of Iranian herbal medicine on methicillin-resistant Staphylococcus aureus. Jundishapur J Chronic Dis Care. 2019; 8(4): e96058. [DOI:10.5812/jjcdc.96058]
9. Mahboubi M, Bidgoli FG. Biological activity of essential oil from aerial parts of Artemisia aucheri Boiss. from Iran. Herba Pol. 2009; 55(4): 96-104.
10. Ki V, Rotstein C. Bacterial skin and soft tissue infections in adults: a review of their epidemiology, pathogenesis, diagnosis, treatment and site of care. Can J Infect Dis Med Microbiol. 2008; 19(2): 173-84. [DOI:10.1155/2008/846453] [PMID] []
11. Abad MJ, Bedoya LM, Apaza L, Bermejo P. The Artemisia L. genus: a review of bioactive essential oils. Molecules. 2012; 17(3): 2542-66. [DOI:10.3390/molecules17032542] [PMID] []
12. Bora KS, Sharma A. The genus Artemisia: a comprehensive review. Pharm Biol. 2011; 49(1): 101-9. [DOI:10.3109/13880209.2010.497815] [PMID]
13. Miraldi E, Ferri S, Mostaghimi V. Botanical drugs and preparations in the traditional medicine of West Azerbaijan (Iran). J Ethnopharmacol. 2001; 75(2-3): 77-87. [DOI:10.1016/S0378-8741(00)00381-0] [PMID]
14. Ghorbani A. Studies on pharmaceutical ethnobotany in the region of Turkmen Sahra, north of Iran:(Part 1): General results. J Ethnopharmacol. 2005; 102(1): 58-68. [DOI:10.1016/j.jep.2005.05.035] [PMID]
15. Msaada K, Salem N, Bachrouch O, Bousselmi S, Tammar S, Alfaify A, et al. Chemical composition and antioxidant and antimicrobial activities of wormwood (Artemisia absinthium L.) essential oils and phenolics. J Chem. 2015; 12(2): 44-48. [DOI:10.1155/2015/804658]
16. Tayefeh HE, Sefidkon F, Yousefi M, Teimouri M. Essential oil composition and antimicrobial activities of oil, alcoholic extract of Artemisia sieberi from Firoozkooh region. Iran J Biol. 2012; 25(3): 445-455. [Full text in Persian]
17. Jang J, Hur HG, Sadowsky MJ, Byappanahalli M, Yan T, Ishii S. Environmental Escherichia coli: ecology and public health implications. J Appl Microbiol. 2017; 123(3): 570-581. [DOI:10.1111/jam.13468] [PMID]
18. Wu W, Jin Y, Bai F, Jin S. Pseudomonas aeruginosa, in: Tang Y W, Liu D, Sussman M, Poxton I, Schwartzman J. (Eds.) Molecular Medical Microbiology, Academic Press, Cambridge: pp. 753-767. [DOI:10.1016/B978-0-12-397169-2.00041-X]
19. Bassetti M, Vena A, Croxatto A, Righi E, Guery B. How to manage Pseudomonas aeruginosa infections. Drugs Context. 2018; 7: 212527. [DOI:10.7573/dic.212527] [PMID] []
20. Wagner S, Sommer R, Hinsberger S, Lu C, Hartmann RW, Empting M, et al. Novel strategies for the treatment of Pseudomonas aeruginosa infections. J Med Chem. 2016; 59(13): 5929-69. [DOI:10.1021/acs.jmedchem.5b01698] [PMID]
21. Calfee DP. Recent advances in the understanding and management of Klebsiella pneumoniae. F1000Res. 2017;6:1760. [DOI:10.12688/f1000research.11532.1] [PMID] []
22. Effah CY, Sun T, Liu S, Wu Y. Klebsiella pneumoniae: an increasing threat to public health. Ann clin microbiol antimicrob. 2020; 19(1): 1-9. [DOI:10.1186/s12941-019-0343-8] [PMID] []
23. Percival SL, Williams DW. Acinetobacter. In: Percival SL, Yates MV, Williams DW, Chalmers RM, Gray NF. Microbiology of Waterborne Diseases, 2nd ed. London: Academic Press, 2014: 35-48. [DOI:10.1016/B978-0-12-415846-7.00002-0]
24. Hosseinzadeh L, Soheili S, Ghiasvand N, Ahmadi F, Shokoohinia Y. Fatty acid mixtures from Nigella sativa protects pc12 cells from oxidative stress and apoptosis induced by doxorubicin. Pharm Sci. 2018; 24(1): 15-22. [DOI:10.15171/PS.2018.04]
25. Hatami T, Emami SA, Miraghaee SS, Mojarrab M. Total phenolic contents and antioxidant activities of different extracts and fractions from the aerial parts of Artemisia biennis Willd. Iran J Pharm Res. 2014; 13(2): 551-559.
26. Clinical and laboratory standards institute (CLSI) performance standards for antimicrobial susceptibility testing. 28th ed. clinical and laboratory standards institute; Wayne, PA, USA: 2018; CLSI Supplement M100.Available from: https://clsi.org/media/1930/m100ed28_sample.pdf
27. Olennikov DN, Kashchenko NI, Chirikova NK, Vasil'eva AG, Gadimli AI, Isaev JI, et al. Caffeoylquinic acids and flavonoids of fringed sagewort (Artemisia frigida Willd.): HPLC-DAD-ESI-QQQ-MS profile, HPLC-DAD quantification, in vitro digestion stability, and antioxidant capacity. Antioxidants. 2019; 8(8): 307. [DOI:10.3390/antiox8080307] [PMID] []
28. Moradi-Afrapoli F, Saremi G, Nasseri S, Emami SA, Mojarrab M. Isolation of two isochlorogenic acid isomers from phenolic rich fraction of Artemisia turanica Krasch. Iran J Pharm Res. 2020; 19(4): 59-66.
29. Nasseri S, Emami SA, Mojarrab M. Dicaffeoylquinic acids from the aerial parts of Artemisia ciniformis Krasch. & Popov ex Poljakov. Pharm Sci. 2019; 25(2): 171-5. [DOI:10.15171/PS.2019.25]
30. Ghasemi G, Alirezalu A, Ishkeh SR, Ghosta Y. Phytochemical properties of essential oil from Artemisia sieberi Besser (Iranian accession) and its antioxidant and antifungal activities. Nat Prod Res. 2021; 35(21): 4154-4158. [DOI:10.1080/14786419.2020.1741576] [PMID]
31. Silva NC, Fernandes Júnior AJ. Biological properties of medicinal plants: a review of their antimicrobial activity. J Venom Anim Toxins Incl Trop Dis. 2010; 16(3): 402-413. [DOI:10.1590/S1678-91992010000300006]
32. Abiri R, Ghasemi S, Bagheri M, Shahbazi M, Emami SA, Mojarrab M. The comparative study on in vitro antibacterial effects of different aqueous extracts of Artemisia species. J Ardabil Univ Med Sci. 2023; 23(3): 309-319. [Full text in Persian] [DOI:10.61186/jarums.23.3.309]
33. Lee AS, De Lencastre H, Garau J, Kluytmans J, Malhotra-Kumar S, Peschel A, et al. Methicillin-resistant Staphylococcus aureus. Nat Rev Dis Primers. 2018; 31(1): 1-23. [DOI:10.1038/nrdp.2018.33] [PMID]
34. Rolta R, Sharma A, Sourirajan A, Mallikarjunan PK, Dev K. Combination between antibacterial and antifungal antibiotics with phytocompounds of Artemisia annua L: A strategy to control drug resistance pathogens. J Ethnopharmacol. 2021; 266: 113420. [DOI:10.1016/j.jep.2020.113420] [PMID]
35. Sardarodiyan M, Arian Far A. Investigation of chemical components, antibacterial and antioxidant properties of Essential Oil Artemisia Khorasanica in north Khorasan area. Innovation Food Sci Technol. 2019; 11(1): 39-57.
36. Nasirpour M, Yavarmanesh M, Mohhamadi Sani A, Mohamdzade Moghadam M. Antibacterial effect of aqueous extract of Artemisia aucheri, Artemisia sieberi and Hyssopus officinalis L. on the food borne pathogenic bacteria. FSCT. 2015; 12(46): 73-84. [Full text in Persian]
37. Haji Ghasemi M, Govahi M, Ranjbar M. Evaluation of antibacterial activity of aqueous and hydroalcoholic extracts of Physalis alkekengi fruit against four standard strains in vitro. J Ardabil Univ Med Sci. 2023; 22(4): 323-332. [Full text in Persian] [DOI:10.52547/jarums.22.4.323]
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA

Ethics code: IR.KUMS.REC.1401.277



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Abiri R, Ghasemi S, Sharei N, Shahbazi M, Emami A, Mojarrab M. The Comparative Study of Antibacterial Effects of Different Hydroethanolic Extracts of Artemisia Species against Common Bacterial Strains in Nosocomial Infections. J Ardabil Univ Med Sci 2024; 24 (1) : 8
URL: http://jarums.arums.ac.ir/article-1-2355-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 24, Issue 1 (Spring 2024) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
Persian site map - English site map - Created in 0.16 seconds with 41 queries by YEKTAWEB 4623