Background & Objective: Many factors interfere in liver fibrosis one of which is hepatitis B.The aim of our study was to determine the parameters serum iron, TIBC and ferritin of patients with hepatitis B and fibrosis of the liver

Methods: Study involved 50 cases with liver fibrosis and viral hepatitis type B (2002-2004)
and 26 controls. Iron concentration, Total iron-binding capacity and Ferritin concentration were measured by standard biochemical methods. To compare the results of the two groyps a student t-test was used and considering p< 0.05 the difference between two groups was significant.

Results: The results showed that serum ferritin increase 243.7±16.7 micro gr/L and 238.7±13.9 micro gr/L in man and women patients with chronic hepatitis B virus infection compared to the control group, 198.5±14.3 and 182.7 ±14.3 mg/L in man and women, respectively. No significant difference was found between serum Iron and TIBC in both groups. there was a significant relationship between them.

Conclusion: Increased serum ferritin concentration and liver fibrosis induced by hepatitis B virus infection. Also, determination of serum ferritin could help in diagnosis of liver fibrosis.