Evaluation of the Effect of Aspirin Consumption on the Patency of Permanent Internal Jugular Dialysis Catheters in Patients with End-Stage Renal Disease: A Randomized Clinical Trial

Davoodi, Hanieh; Agha Rafiei, Nadia; Haji Salimi, Bahareh

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Evaluation of the Effect of Aspirin Consumption on the Patency of Permanent Internal Jugular Dialysis Catheters in Patients with End-Stage Renal Disease: A Randomized Clinical Trial

Hanieh Davoodi

, Nadia Agha Rafiei

, Bahareh Haji Salimi ^*

Department of Internal Medicine, Vali-Asr Hospital, Zanjan University of Medical Sciences, Zanjan, Iran , bahareh77@zums.ac.ir

Abstract: (54 Views)

Background: Patients with end-stage renal disease (ESRD) usually require central venous dialysis catheters, particularly tunneled permanent internal jugular catheters, for hemodialysis access. Complications such as thrombosis and catheter dysfunction are among the major factors that reduce the effectiveness of dialysis treatment. Numerous studies have investigated the effects of antiplatelet and anticoagulant drugs on the patency of hemodialysis vascular access; however, most of these studies have focused on arteriovenous grafts and fistulas or on the use of high-dose aspirin in combination with other drugs, while the effect of low-dose aspirin alone on the patency of central venous catheters has received little attention. Considering this research gap and the clinical need for strategies to prolong catheter lifespan and reduce the costs associated with frequent replacements, this study was designed and conducted to evaluate the effect of low-dose aspirin on the patency of permanent internal jugular dialysis catheters in patients with ESRD.
Methods: In this randomized clinical trial, 84 patients with ESRD and permanent internal jugular dialysis catheters were randomly assigned to two equal groups (aspirin and placebo, 42 patients each) using simple randomization. The intervention group received 80 mg of aspirin daily, while the control group received a placebo. Patients were followed for six months. Demographic data, underlying conditions, and catheter survival time were recorded and analyzed using SPSS version 26. Catheter survival between the intervention and control groups was analyzed using the Kaplan–Meier method (cumulative failure function) and the Log-rank test. Subgroup analyses by age, sex, and comorbidities (diabetes, hypertension, and heart failure) were also performed to assess their association with catheter survival.
Results: Catheter dysfunction occurred in 9.5% of the aspirin group and 21.4% of the control group. The mean catheter survival was 168.09 days in the aspirin group and 160.08 days in the control group. The difference in survival between the two groups was not statistically significant. None of the variables including, age, gender, diabetes, hypertension, or heart failure were significantly associated with catheter patency.
Conclusion: Daily administration of 80 mg aspirin had no significant effect on increasing the survival time of permanent tunneled internal jugular dialysis catheters in ESRD patients. Further studies with larger populations and longer follow-up periods are recommended for more definitive results.

Keywords: Aspirin, End-stage Renal Disease, Permanent Dialysis Catheter, Internal Jugular Vein

Full-Text [PDF 502 kb] (21 Downloads)

Type of Study: article | Subject: Urology-nephrology
Received: 2025/08/22 | Accepted: 2025/09/27

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