[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 22, Issue 4 (Winter 2022) ::
J Ardabil Univ Med Sci 2022, 22(4): 393-408 Back to browse issues page
Fabrication and Characterization of Betamethasone-loaded Oral Thin Films as a Novel Drug Delivery Platform for Oral Lichen Planus and Recurrent Mouth Ulcers
Sadaf Khaki , Nastaran Hadizadeh , Leila Rezaie Shirmard *
Department of Pharmaceutics, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran
Abstract:   (211 Views)
Background & objectives: Due to the existence of various issues and limitations associated with traditional buccal drug delivery systems such as the disability to consume food whilst using topical drugs in the mouth cavity, unpredictable drug release profile, undesirable taste, low patient adherence to therapy, and accelerated drug removal with saliva, these conventional methods are now rapidly becoming replaced with oral thin films as more precise and novel oral drug delivery platforms. The current study aims to discuss the design and characterization of betamethasone-loaded oral thin films with the aim of improved drug delivery in mouth cavity diseases.
Methods: In this study, oral thin films with and without betamethasone were fabricated through the solvent casting method as a common, fast, and affordable technique prior to being evaluated for different physiochemical characteristics including weight, width, surface pH, disintegration period in vitro conditions, and swelling rates as well as drug release profiles at different intervals.
Results: Obtained oral films were demonstrated to possess adequate homogeneity, flexibility, and mechanical resistance. Accordingly, the average surface pH for films without and with betamethasone was equal to 6.75 and 6.66, respectively, which are in notable compatibility with the neutral pH of the oral cavity. Betamethasone-loaded films’ disintegration duration appeared to be superior to that of films without betamethasone and was in close correlation with their higher swelling rates. Further experiments revealed 25-30% drug release in the initial 20 minutes, followed by more than 90% betamethasone release in 360 minutes in a sustained manner.
Conclusion: These results are indicative of betamethasone oral films’ satisfactory physiochemical properties and potential applicability as a sufficient oral drug delivery platform in mouth cavity diseases such as oral lichen planus or recurrent mouth sores. By sticking to the mouth mucosa, these films can significantly reduce drug removal with saliva and thus ameliorate sufficient delivery of therapeutic agents to specific mouth lesions. Moreover, they can alleviate some of the issues and limitations of traditional topical oral drug delivery and improve treatment or control of disease symptoms.
Article number: 7
Keywords: Oral Thin Films, Oral Drug Delivery, Mouth Sores, Betamethasone, Drug Delivery Systems
Full-Text [PDF 1032 kb]   (355 Downloads)    
Type of Study: article | Subject: فارماکولوژی
Received: 2023/01/24 | Accepted: 2023/04/3 | Published: 2022/12/31
Send email to the article author

Add your comments about this article
Your username or Email:


Ethics code: IR.ARUMS.REC.1398.633

XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Khaki S, Hadizadeh N, Rezaie Shirmard L. Fabrication and Characterization of Betamethasone-loaded Oral Thin Films as a Novel Drug Delivery Platform for Oral Lichen Planus and Recurrent Mouth Ulcers. J Ardabil Univ Med Sci 2022; 22 (4) :393-408
URL: http://jarums.arums.ac.ir/article-1-2254-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 22, Issue 4 (Winter 2022) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
Persian site map - English site map - Created in 0.06 seconds with 30 queries by YEKTAWEB 4502