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:: Volume 10, Issue 2 (summer 2010) ::
J Ardabil Univ Med Sci 2010, 10(2): 145-154 Back to browse issues page
Effect of oral morphine consumption on maternal and fetal portion placenta cells development in Wistar rat
Masoumeh Kazemi *, Hedayat Sahraie, Mahnaz Azarnia, Hosein Bahadoran
Abstract:   (6775 Views)

 Background & Objectives: Previous studies indicated that morphine consumption during pregnancy could inhibit embryos development. Present study further evaluated the effects of oral morphine consumption on the maternal and fetal portion placenta cells development in Wistar rats.

 Methods: Female Wistar rats (W: 170-200 g) were used in the present study. Morphine group were received morphine (0.05 mg/ml of tap water) after one night coupling with male rats for mating. On 14th, 17th days of pregnancy, the pregnant animals were killed with chloroform and the placentas and uterus were removed surgically and fixed in 10 % formalin. The fixed placentas and uterus were stained by H & E method and evaluated for their development. The thickness of layers, as well as number of the cells in both maternal and fetal parts of the placentas was determined by light microscopy and processed using MOTIC software.

 Results: The results indicated that oral consumption of morphine compared to control group, increased the thickness of the layers in maternal portion and also, increased the number of the cells in both maternal and fetal portion of the placenta.

 Conclusion: All together, oral morphine consumption may inhibit placenta cells development and disturb their natural functions. These abnormalities observed in the placenta by opioid addicted pregnancy Wistar rats.

Keywords: Placenta cells, Morphine, Rat
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Type of Study: article | Subject: Special
Received: 2010/02/20 | Accepted: 2010/08/3 | Published: 2010/10/17
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Kazemi M, Sahraie H, Azarnia M, Bahadoran H. Effect of oral morphine consumption on maternal and fetal portion placenta cells development in Wistar rat. J Ardabil Univ Med Sci. 2010; 10 (2) :145-154
URL: http://jarums.arums.ac.ir/article-1-225-en.html


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Volume 10, Issue 2 (summer 2010) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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