Background &Objectives: Antiemetic drugs can be used in complicated cases of vomiting secondary to gastroenteritis. There is no previous study dealing with the use of pyridoxine in treatment of vomiting in pediatrics. This Studyintendsto review the effects of intravenous pyridoxine on control of gastroenteritis related vomiting.

  Methods: This study is a single blind randomized clinical trial with placebo. A total number of 147 children diagnosed with gastroenteritis induced vomiting and admitted in Amirkabir hospital from August to December 2011 were studied and divided to two case andcontrol groups. In the control group intravenous fluid with distilled water (placebo) was used and the pyridoxine was given along with intravenous fluid therapy in case group. Since admission for three days, numbers of vomiting and other symptoms were collected in data form. Results were analyzed using SPSS-16 by means of descriptive analysis for basic information.

  Results: Most children were male, aged between 6 months and 2 years and having urban life. There was no significant difference between two groups in the mean of vomiting frequency during the period of hospitalization ( p>0.05 ). T here was also no significant difference between two groups in duration of hospitalization ( p=0.19).

  Conclusion: Based on this study pyridoxine (Vitamin B6) was not effective in treatment of vomiting due to gastroenteritis in children, and did not reduce the duration of hospitalization.