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:: Volume 16, Issue 1 (spring 2016) ::
J Ardabil Univ Med Sci 2016, 16(1): 16-22 Back to browse issues page
Association of G103T Polymorphism of Coagulation Factor XIII with Recurrent Pregnancy Loss in Northwest of Iran
Morteza Bonyadi *, Saba AhmadpourNazm, Simin Taghavi, Farzam Ajamian
Center of Excellence for Biodiversity, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
Abstract:   (7811 Views)

Background & objectives: Recurrent miscarriage (RM) occurs in 1–3% of couples attempting to bear children. Thrombophilia is one of the suspected causes of recurrent miscarriage. The factor XIII makes the clot stable at the end of coagulation cascade. The polymorphism G103T of factor XIII gene is the most common polymorphism that affects F XIII activity. We aimed to study the possible association of FXIII gene polymorphism (V34L) with recurrent miscarriage among patients in Northwest of Iran.

Methods: The study groups consisted of 70 patients with two or more consecutive miscarriages. The control group included 50 women with at least two successful deliveries and no history of pregnancy loss.  DNA from both groups analyzed for carrying mutation of FXIII by PCR-RFLP. The  test used for statistical analyze.

Results: Two patients (%2.85) in the case group were homozygote (TT) for 34 Leu mutation whereas no homozygote (TT) was found in control group (p>0.05). 19 patients (%27.1) in the case group and 13 women (%26) in the control group were found to be heterozygote for G103T polymorphism (p>0.05). No significant difference was observed between patients with RPL and healthy women for G103T mutation.

Conclusion: No statistically difference was observed between case and control group.

Keywords: Recurrent Miscarriage, Thrombophilia, F XIII
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Type of Study: article | Subject: General
Received: 2015/07/11 | Accepted: 2015/12/21 | Published: 2016/04/14
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Bonyadi M, AhmadpourNazm S, Taghavi S, Ajamian F. Association of G103T Polymorphism of Coagulation Factor XIII with Recurrent Pregnancy Loss in Northwest of Iran. J Ardabil Univ Med Sci. 2016; 16 (1) :16-22
URL: http://jarums.arums.ac.ir/article-1-1039-en.html


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Volume 16, Issue 1 (spring 2016) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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