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:: Volume 24, Issue 1 (Spring 2024) ::
J Ardabil Univ Med Sci 2024, 24(1): 92-106 Back to browse issues page
The Effect of Physical Activity on Stress and Inflammation in Mice with Rheumatoid Arthritis
Sheida Payamipour , Maghsoud Peeri * , Mohammad Ali Azarbaijani , Forouzan Fattahi Masrour
Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran , m.peeri@iauctb.ac.ir
Abstract:   (124 Views)
Background: Rheumatoid arthritis is an autoimmune disease that gradually destroys the synovial joints and leads to chronic inflammation. This autoimmune disorder is associated with an increase in stress-related symptoms, including anxiety and depression, and a decrease in social behaviors, which severely reduces the patient's quality of life. Previous studies show that higher physical activity during adolescence may lead to a decrease in neurobehavioral disorders in adulthood. This study was conducted with the aim of evaluating the increase of physical activity from early adolescence on stress-related behaviors and inflammation in mice with rheumatoid arthritis.
Methods: Male mice were randomly exposed to a running wheel from early adolescence to adulthood, and then rheumatoid arthritis was induced. Stress-related behaviors, including anxiety, depression and social behavior were investigated in animals. The level of interleukin 17 (IL-17) and interferon gamma (IFN-γ) were also measured as important inflammatory markers in the serum.
Results: The results showed that physical activity from early adolescence significantly resulted in decreased stress in mice with rheumatoid arthritis. In addition, the running wheel led to a decrease in the levels of (IL-17) and (IFN-γ) in rheumatoid arthritis-induced mice as two important indicators of inflammation.
Conclusion: This study shows that increased physical activity during adolescence to adulthood may make mice resistant to increased stress and inflammation caused by rheumatic arthritis.

 
Article number: 7
Keywords: Exercise, Stress, Rheumatoid Arthritis, Inflammation
Full-Text [PDF 846 kb]   (84 Downloads)    
Type of Study: article | Subject: Exercise physiology
Received: 2024/04/26 | Accepted: 2024/07/13 | Published: 2024/08/5
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Payamipour S, Peeri M, Azarbaijani M A, Fattahi Masrour F. The Effect of Physical Activity on Stress and Inflammation in Mice with Rheumatoid Arthritis. J Ardabil Univ Med Sci 2024; 24 (1) : 7
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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 24, Issue 1 (Spring 2024) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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