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:: Volume 24, Issue 1 (Spring 2024) ::
J Ardabil Univ Med Sci 2024, 24(1): 92-106 Back to browse issues page
The Effect of Physical Activity on Stress and Inflammation in Mice with Rheumatoid Arthritis
Sheida Payamipour , Maghsoud Peeri * , Mohammad Ali Azarbaijani , Forouzan Fattahi Masrour
Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran , m.peeri@iauctb.ac.ir
Abstract:   (117 Views)
Background: Rheumatoid arthritis is an autoimmune disease that gradually destroys the synovial joints and leads to chronic inflammation. This autoimmune disorder is associated with an increase in stress-related symptoms, including anxiety and depression, and a decrease in social behaviors, which severely reduces the patient's quality of life. Previous studies show that higher physical activity during adolescence may lead to a decrease in neurobehavioral disorders in adulthood. This study was conducted with the aim of evaluating the increase of physical activity from early adolescence on stress-related behaviors and inflammation in mice with rheumatoid arthritis.
Methods: Male mice were randomly exposed to a running wheel from early adolescence to adulthood, and then rheumatoid arthritis was induced. Stress-related behaviors, including anxiety, depression and social behavior were investigated in animals. The level of interleukin 17 (IL-17) and interferon gamma (IFN-γ) were also measured as important inflammatory markers in the serum.
Results: The results showed that physical activity from early adolescence significantly resulted in decreased stress in mice with rheumatoid arthritis. In addition, the running wheel led to a decrease in the levels of (IL-17) and (IFN-γ) in rheumatoid arthritis-induced mice as two important indicators of inflammation.
Conclusion: This study shows that increased physical activity during adolescence to adulthood may make mice resistant to increased stress and inflammation caused by rheumatic arthritis.

 
Article number: 7
Keywords: Exercise, Stress, Rheumatoid Arthritis, Inflammation
Full-Text [PDF 846 kb]   (81 Downloads)    
Type of Study: article | Subject: Exercise physiology
Received: 2024/04/26 | Accepted: 2024/07/13 | Published: 2024/08/5
References
1. Gerosa M, De Angelis V, Riboldi P, Meroni PL. Rheumatoid arthritis: a female challenge. Women's Health. 2008;4(2):195-201. [DOI:10.2217/17455057.4.2.195] [PMID]
2. Almutairi KB, Nossent JC, Preen DB, Keen HI, Inderjeeth CA. The prevalence of rheumatoid arthritis: a systematic review of population-based studies. J Rheumatol. 2021;48(5):669-676. [DOI:10.3899/jrheum.200367] [PMID]
3. Covic T, Cumming SR, Pallant JF, Manolios N, Emery P, Conaghan PG, et al. Depression and anxiety in patients with rheumatoid arthritis: prevalence rates based on a comparison of the Depression, Anxiety and Stress Scale (DASS) and the hospital, Anxiety and Depression Scale (HADS). BMC Psychiatry. 2012;12(1):1-10. [DOI:10.1186/1471-244X-12-6] [PMID] []
4. Beşirli A, Alptekin JÖ, Kaymak D, Özer ÖA. The relationship between anxiety, depression, suicidal ideation and quality of life in patients with rheumatoid arthritis. Psychiatr Q. 2020;91:53-64. [DOI:10.1007/s11126-019-09680-x] [PMID]
5. Enayati M, Solati J, Hosseini MH, Shahi HR, Saki G, Salari AA. Maternal infection during late pregnancy increases anxiety- and depression-like behaviors with increasing age in male offspring. Brain Res Bull. 2012;87(2-3):295-302. [DOI:10.1016/j.brainresbull.2011.08.015] [PMID]
6. Benedetti G, Miossec P. Interleukin 17 contributes to the chronicity of inflammatory diseases such as rheumatoid arthritis. Eur J Immunol. 2014;44(2):339-347. [DOI:10.1002/eji.201344184] [PMID]
7. Kuwabara T, Ishikawa F, Kondo M, Kakiuchi T. The role of IL-17 and related cytokines in inflammatory autoimmune diseases. Mediators Inflamm. 2017; 3908061. [DOI:10.1155/2017/3908061] [PMID] []
8. Metawi SA, Abbas D, Kamal MM, Ibrahim MK. Serum and synovial fluid levels of interleukin-17 in correlation with disease activity in patients with RA. Clin Rheumatol. 2011;30(9):1201-1207. [DOI:10.1007/s10067-011-1737-y] [PMID]
9. Sarkar S, Cooney LA, White P, Dunlop DB, Endres J, Jorns JM, et al. Regulation of pathogenic IL-17 responses in collagen-induced arthritis: roles of endogenous interferon-gamma and IL-4. Arthritis Res Ther. 2009;11(5):1-15. [DOI:10.1186/ar2838] [PMID] []
10. Ren H, Lin F, Wu L, Tan L, Lu L, Xie X, et al. The prevalence and the effect of interferon-γ in the comorbidity of rheumatoid arthritis and depression. Behav Brain Res. 2023;439:114237. [DOI:10.1016/j.bbr.2022.114237] [PMID]
11. Liu Y, HO RC, Mak A. The role of interleukin (IL)‐17 in anxiety and depression of patients with rheumatoid arthritis. Int J Rheum Dis. 2012;15(2):183-187. [DOI:10.1111/j.1756-185X.2011.01673.x] [PMID]
12. Metsios GS, Kitas GD. Physical activity, exercise and rheumatoid arthritis: effectiveness, mechanisms and implementation. Best Pract Res Clin Rheumatol. 2018;32(5):669-682. [DOI:10.1016/j.berh.2019.03.013] [PMID]
13. Cooney JK, Law RJ, Matschke V, Lemmey AB, Moore JP, Ahmad Y, et al. Benefits of exercise in rheumatoid arthritis. J Aging Res. 2011; 681640. [DOI:10.4061/2011/681640] [PMID] []
14. Ebrahimian F, Najdi N, Masrour FF, Salari AA. Swimming exercise strain-dependently affects maternal care and depression-related behaviors through gestational corticosterone and brain serotonin in postpartum dams. Brain Res Bull. 2022;188:122-130. [DOI:10.1016/j.brainresbull.2022.07.020] [PMID]
15. Barzegari A, Mahdirejei HA, Hanani M, Esmaeili MH, Salari AA. Adolescent swimming exercise following maternal valproic acid treatment improves cognition and reduces stress-related symptoms in offspring mice: Role of sex and brain cytokines. Physiol Behav. 2023;114264. [DOI:10.1016/j.physbeh.2023.114264] [PMID]
16. Naghibi S, Shariatzadeh M, Barzegari A, Davoodabadi A, Ebrahimi A, Eghdami E, et al. Treadmill exercise sex-dependently alters susceptibility to depression-like behaviour, cytokines and BDNF in the hippocampus and prefrontal cortex of rats with sporadic Alzheimer-like disease. Physiol Behav. 2021;113595. [DOI:10.1016/j.physbeh.2021.113595] [PMID]
17. Naghibi S, Barzegari A, Shariatzadeh M, Vatandoost M, Ahmadi M, Mahdinia E, et al. Voluntary physical activity increases maternal care and reduces anxiety-and depression-related behaviours during the postpartum period in mice. Brain Res. 2022;147880. [DOI:10.1016/j.brainres.2022.147880] [PMID]
18. Shekarchian M, Peeri M, Azarbayjani MA. Physical activity in a swimming pool attenuates memory impairment by reducing glutamate and inflammatory cytokines and increasing BDNF in the brain of mice with type 2 diabetes. Brain Res Bull. 2023;201:110725. [DOI:10.1016/j.brainresbull.2023.110725] [PMID]
19. Gilak‐Dalasm M, Peeri M, Azarbayjani MA. Swimming exercise decreases depression‐like behaviour and inflammatory cytokines in a mouse model of type 2 diabetes. Exp Physiol. 2021;106(9):1981-1991. [DOI:10.1113/EP089501] [PMID]
20. Matinfar P, Peeri M, Azarbayjani MA. Swimming exercise attenuates anxiety-like behavior by reducing brain oxidative stress in type 2 diabetic mice. Physiol Behav. 2021;237:113449. [DOI:10.1016/j.physbeh.2021.113449] [PMID]
21. Sadeghi M, Peeri M, Hosseini MJ. Adolescent voluntary exercise attenuated hippocampal innate immunity responses and depressive-like behaviors following maternal separation stress in male rats. Physiol Behav. 2016;163:177-183. [DOI:10.1016/j.physbeh.2016.05.017] [PMID]
22. Zolfaghari FS, Pirri F, Gauvin E, Peeri M, Amiri S. Exercise and fluoxetine treatment during adolescence protect against early life stress-induced behavioral abnormalities in adult rats. Pharmacol Biochem Behav. 2021;205:173190. [DOI:10.1016/j.pbb.2021.173190] [PMID]
23. Yang K, Tong L, Chen C, Zhang P, Pi H, Ruan H, et al. Therapeutic effects of extracts from Radix Toddaliae Asiaticae on collagen-induced arthritis in Balb/c mice. J Ethnopharmacol. 2013;146(1):355-362. [DOI:10.1016/j.jep.2013.01.004] [PMID]
24. Salari AA, Bakhtiari A, Homberg JR. Activation of GABA-A receptors during postnatal brain development increases anxiety- and depression-related behaviors in a time- and dose-dependent manner in adult mice. Eur Neuropsychopharmacol. 2015;25(8):1260-1274. [DOI:10.1016/j.euroneuro.2015.04.022] [PMID]
25. Babri S, Doosti MH, Salari AA. Strain-dependent effects of prenatal maternal immune activation on anxiety- and depression-like behaviors in offspring. Brain Behav Immun. 2014;37:164-176. [DOI:10.1016/j.bbi.2013.12.003] [PMID]
26. Minor MA, Webel RR, Kay DR, Hewett JE, Anderson SK. Efficacy of physical conditioning exercise in patients with rheumatoid arthritis and osteoarthritis. Arthritis Rheumatol. 1989;32(11):1396-1405. [DOI:10.1002/anr.1780321108] [PMID]
27. Kucharski D, Lange E, Ross AB, Svedlund S, Feldthusen C, Önnheim K, et al. Moderate-to-high intensity exercise with person-centered guidance influences fatigue in older adults with rheumatoid arthritis. Rheumatol Int. 2019;39(9):1585-1594. [DOI:10.1007/s00296-019-04384-8] [PMID]
28. Waite‐Jones JM, Hale CA, Lee H. Psychosocial effects of T ai C hi exercise on people with rheumatoid arthritis. J Clin Nurs. 2013;22(21-22):3053-3061. [DOI:10.1111/jocn.12327] [PMID]
29. Kany S, Vollrath JT, Relja B. Cytokines in inflammatory disease. Int J Mol Sci. 2019;20(23):6008. [DOI:10.3390/ijms20236008] [PMID] []
30. Balchin C, Tan AL, Golding J, Bissell LA, Wilson OJ, McKenna J, et al. Acute effects of exercise on pain symptoms, clinical inflammatory markers and inflammatory cytokines in people with rheumatoid arthritis: a systematic literature review. Ther Adv Musculoskelet Dis. 2022;14:1759720X221114104. [DOI:10.1177/1759720X221114104] [PMID] []
31. Duzova H, Karakoc Y, Emre MH, Dogan ZY, Kilinc E. Effects of acute moderate and strenuous exercise bouts on IL-17 production and inflammatory response in trained rats. J Sports Sci Med. 2009;8(2):219-224.
32. García JJ, Bote E, Hinchado MD, Ortega E. A single session of intense exercise improves the inflammatory response in healthy sedentary women. J Physiol Biochem. 2011;67:87-94. [DOI:10.1007/s13105-010-0052-4] [PMID]
33. Castellano V, Patel DI, White LJ. Cytokine responses to acute and chronic exercise in multiple sclerosis. J Appl Physiol. 2008;104(6):1697-1702. [DOI:10.1152/japplphysiol.00954.2007] [PMID]
34. Kim J, Suh YH, Chang KA. Interleukin-17 induced by cumulative mild stress promoted depression-like behaviors in young adult mice. Mol Brain. 2021;14:1-13. [DOI:10.1186/s13041-020-00726-x] [PMID] []
35. Li Y, Chou Y, Chen H, Lu C, Chang D. Interleukin‐6 and interleukin‐17 are related to depression in patients with rheumatoid arthritis. Int J Rheum Dis. 2019;22(6):980-985. [DOI:10.1111/1756-185X.13529] [PMID]
36. Zhang J, He H, Qiao Y, Zhou T, He H, Yi S, et al. Priming of microglia with IFN‐γ impairs adult hippocampal neurogenesis and leads to depression‐like behaviors and cognitive defects. Glia. 2020;68(12):2674-2692. [DOI:10.1002/glia.23878] [PMID]
37. Ren H, Lin F, Wu L, Tan L, Lu L, Xie X, et al. The prevalence and the effect of interferon-γ in the comorbidity of rheumatoid arthritis and depression. Behav Brain Res. 2023;439:114237. [DOI:10.1016/j.bbr.2022.114237] [PMID]
38. Steensberg A, Toft AD, Bruunsgaard H, Sandmand M, Halkjær-Kristensen J, Pedersen BK. Strenuous exercise decreases the percentage of type 1 T cells in the circulation. J Appl Physiol. 2001;91(4):1708-1712. [DOI:10.1152/jappl.2001.91.4.1708] [PMID]
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Payamipour S, Peeri M, Azarbaijani M A, Fattahi Masrour F. The Effect of Physical Activity on Stress and Inflammation in Mice with Rheumatoid Arthritis. J Ardabil Univ Med Sci 2024; 24 (1) : 7
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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 24, Issue 1 (Spring 2024) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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