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:: Volume 15, Issue 3 (autumn 2015) ::
J Ardabil Univ Med Sci 2015, 15(3): 277-282 Back to browse issues page
Prevalence of Human Leukocyte Antigen (HLA DQ2 and DQ8) in Celiac Disease in Patients with Irritable Bowel Syndrome
A Houshiyar, N Fouladi *, F Ghorbani, R Mohammadi, H AlimohammadiAsl
Abstract:   (8780 Views)

Background &objectives: Celiac disease is a gastrointestinal disorder that genetic factors have a role on its pathogenesis. The aim of the present study was to determine HLA alleles encoding HLA DQ2 and HLA DQ8 in patients with celiac disease.

Methods: This descriptive analytical study was conducted on 105 patients with IBS whom referred to the gastroenterology unit in Ardabil, Iran. The patients with positive celiac serology of IgA anti-tTG test were done an endoscopic duodenal biopsy. HLA DQ2 and DQ8 testings were performed on patients. Data were analyzed using descriptive statistics together with Mann-Whitney U and Fisher&rsquos exact tests by SPSS-16.

Results: 14 patients were found positive for IgA antibodies against tTG. From these 14 patients 2 (14.3%) were male and 12 (85.71%) female. All of 14 patients (100% of case) had also abnormal intestinal pathology according to the modified Marsh classification and 10 patients had type IIIC. 11 patients had only HLA DQ2, 2 patients had only HLADQ8, and one patient had both HLADQ2 andDQ8.

Conclusion: Most of patients had positive HLA D Q2. The present study emphasizes that HLA genotypes are an important background to CD development.

Keywords: Celiac Disease, Irritable Bowel Syndrome, HLADQ2, HLA DQ8
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Received: 2015/10/22 | Accepted: 2015/10/22 | Published: 2015/10/22
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Houshiyar A, Fouladi N, Ghorbani F, Mohammadi R, AlimohammadiAsl H. Prevalence of Human Leukocyte Antigen (HLA DQ2 and DQ8) in Celiac Disease in Patients with Irritable Bowel Syndrome. J Ardabil Univ Med Sci. 2015; 15 (3) :277-282
URL: http://jarums.arums.ac.ir/article-1-899-en.html

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Volume 15, Issue 3 (autumn 2015) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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