Background &objectives: Glutamine has antioxidant properties and can be used to treat some diseases. This study was conducted to assess the effect of one-week glutamine supplementation on oxidative stress indices in young healthy men.

  Methods: Nineteen active healthy men volunteered for this study. This study was conducted in biochemistry lab of Ardabil branch of Islamic Azad University in Spring 2014. Participants were randomized in a double-blind placebo-controlled method into two groups: Glutamine (n = 9) and placebo group (n = 10). The participants took supplement (0.15 g/kg glutamine + 15g sweetener + 250ml water) or placebo (15g sweetener + 250ml water) daily for 7 days before main trial.Fasting blood samples were taken before and after supplementation. Total antioxidant capacity (TAC) of plasma, reduced glutathione (GHS) level of serum, and malondialdehyde (MDA) of plasma were measured.

  Results: GHS significantly increased after treatment compared with pre-treatment in Glutamine group (p<0.05). There were no other within and between group significant differences in any indices (p>0.05).

  Conclusions: These results showed that one-week daily oral supplementation of glutamine has been able to increase GHS probably because of greater glutamine availability .