Background & Objectives: Mitral valve prolapse (MVP) syndrome is one of the most prevalent abnormalities of mitral valve that arises from pathologic changes of the various parts of mitral valve. MVP may lead to ECG changes, like T wave inversion in inferior leads and atrial and ventricular arrhythmias, in some people that may be misdiagnosed as myocardial ischemia.

  Methods: This was an analytical (case-control) study in 50 cases with MVP with age below 30 years who had referred to the Ardabil Bouali Hospital and some private cardiology clinics. The diagnosis of MVP was based on clinical and echocardiographic findings, and after taking history and physical examination, an ECG and an echocardiogram were taken from each person in case and control groups and the acquired information was analyzed via statistical methods of SPSS software.

  Results: From 50 studied cases with MVP, 60% (30 cases) were female and 40% (20 cases) were male, and the most common age range was 21 – 25 years. From these cases, 68% (34 persons) had changes in their ECGs while %32 (16 subjects) did not. In control group, from 50 persons, 44% (22 persons) had ECG changes and 56% (28 persons) did not.

  Conclusion: In general this study showed that increase in ECG changes in MVP group in comparison with control group (p=0.01). In cases with MVP, there was not significant relationship between gender and ECG changes. In comparing case and control groups, there was not significant difference in ECG changes in females, while there was a significant difference in males (14 of 20 versus 6 of 20) w ith considering that ECG changes in persons with MVP may be misdiagnosed as ischemic heart disease,it is recommended that cases (especially men) with MVP always keep a record of their ECGs.