Background & Objectives:�Barrett’s esophagus is the most severe complication of gastroesophageal reflux which may lead to Adenocarcinoma of the esophagus. The epidemiologic aspects of this condition is not completed studied in Iran. The aim of this study is to appraise short segment Barrett’s esophagus in patients which are evaluated due to their reflux related symptoms in a university endoscopy center.

 Methods:�During this cross-sectional study, short segment Barrett’s esophagus was investigated in 100 consequent patients with reflux symptoms (heart burn and/or acid regurgitation) for at least one year. After obtaining their consent for upper endoscope, they were studied interms of short barrett esophagus Four biopsies from esophageal side of gastroesophageal junction for histologic evaluation, and one from antrum for rapid urease test used for Helicobacter pylori were obtained. Barrett’s esophagus was confirmed by appearance of intestinal metaplasia by two pathologists.

  Results: Among 100 eligible subjects, 39 patients were male and 61 were female with a mean (±SD) age of 42.31±15.12 years. Prevalence of short segment Barrett’s esophagus in this study was 8%. Barrett’s esophagus was not related to gender, symptoms and their severity but was significantly more frequent in patients experienced their symptoms for more than 5 years. Barrett’s esophagus was not related to the presence of esophagitis. Infection with Helicobacter pylori was related to less esophagitis but was not related to presence of Barrett’s esophagus.

 Conclusion:�According to the high prevalence of Barrett’s esophagus in subjects with reflux related symptoms in our region, upper gastroesophageal endoscopic evaluation of patients with symptoms more than 5 years is recommended even before age 40. Patients may benefit from Concentration the attention of the endoscopist for taking biopsies.