[Home ] [Archive]   [ فارسی ]  
:: Main In Press Current Issue All Issues Search register ::
Main Menu
Home::
Journal Information::
About the Journal
Aims & Scopes
Indexing
Editorial Board::
Articles archive::
In press
Current Issue
All Issues
For Authors::
Instruction For Authors
Submit your Article
For Reviewers::
Peer Review Policy
Guidelines for Reviewers
Peer review process chart
Editorial Policy::
Authorship Description
Peer-Review Policy
Ethical Considerations
Copyright & Permissions
Data Sharing
Corrections and Retractions
Plagiarism
Registration::
Registration Information
Registration Form
Site Facilities
Most visited articles
Search
Contact us::
Contact Information
Contact us
::
..
Indexing

 

 

 

 

 
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Creative commons

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
..
:: Volume 23, Issue 2 (summer 2023) ::
J Ardabil Univ Med Sci 2023, 23(2): 170-179 Back to browse issues page
Effect of Experimental Alzheimer's disease on the Periodontal Polymorphonuclear (PMN), Eosinophils, Mast Cells, and Collagen Fibers and New Vascularis in Rat
Mohammad Sofiabadi , Fateme Samiee , Mohammad Hossein Esmaeili *
Cellular and Molecular Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran , esmail66@yahoo.com
Abstract:   (656 Views)
Background & objectives: There is a tendency to increase the risk of dementia in patients with periodontitis, but the opposite, the role of Alzheimer's disease on periodontal disease is still unclear, so in this study, the effect of experimental Alzheimer's disease on periodontal inflammatory cells, collagen fibers and neovascularization was investigated in male rats.
Methods: In this experimental study, 16 Wistar male rats (230-250 grams) were randomly divided into 2 groups; control (saline) and streptozotocin 3 mg/kg (bilateral ICV injection, with a volume of 10 μl, in both groups). After 4 weeks of treatment, two groups were tested with the Morris water maze. Then the rats were killed by deep anesthesia and sampling from the papilla around the two central incisor teeth was done. Samples were fixed and the paraffin block was prepared, serial 5-micron slices were made with a microtome. After hematoxylin & eosin staining, the number of inflammatory cells (PMNs, eosinophils, and mast cells), angiogenesis, and fibroblasts were counted using a microscope (400×). Data were analyzed using SPSS 21 software and an independent T-test.
Results: The results showed that Alzheimer's disease causes an increase in periodontal inflammatory cells, collagen fibers and new vessels in the gums of mice, and the difference between these changes between the experimental and control groups was significant in all parameters (p<0.00).
Conclusion: According to these findings, Alzheimer's disease causes or aggravates inflammation and increases the rate of periodontal diseases in rat and may have the same effect in humans.
 
Article number: 6
Keywords: Alzheimer's Disease, Inflammatory Cells, Periodontal Disease, Collagen Fibers, Rat
Full-Text [PDF 467 kb]   (282 Downloads)    
Type of Study: article | Subject: Dentistry
Received: 2023/04/15 | Accepted: 2023/06/27 | Published: 2023/08/30
References
1. Rutger PG. Rheumatoid arthritis and periodontitis - inflammatory and infectious connections. Review of the literature. J Oral Microbiol. 2012; 4: doi: 10.3402/jom.v4i0.11829. [DOI:10.3402/jom.v4i0.11829] [PMID] []
2. Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. J The lancet. 2005; 366: 1809-20. [DOI:10.1016/S0140-6736(05)67728-8] [PMID]
3. Joss A, Alder R, Lang NP. Bleeding on probing: a parameter for monitoring periodontal conditions in clinical practice. J Clin Periodontal. 1994; 21(6):402-408. [DOI:10.1111/j.1600-051X.1994.tb00737.x] [PMID]
4. Armitage GC. The complete periodontal examination. J Periodontal. 2004; 34:22-33. [DOI:10.1046/j.0906-6713.2002.003422.x] [PMID]
5. Kinney JS, Ramseier C, Giannobile WV. Oral fluid-based biomarkers of alveolar bone loss in periodontitis. Ann N Y Acad Sci. 2007; 1098:230-51. [DOI:10.1196/annals.1384.028] [PMID] []
6. Wenk GL. Neuropathologic changes in Alzheimer's disease. J Clin Psychiatry. 2003; 64 Suppl 9:7-10.
7. Khachaturian ZS. Diagnosis of Alzheimer's disease. Arch Neurol. 1985; 42(11): 1097-1105. [DOI:10.1001/archneur.1985.04060100083029] [PMID]
8. Bondi MW, Edmonds EC, Salmon DP. Alzheimer's disease: past, present, and future. J Int Neuropsychol Soc. 2017; 23(9-10):818-31. [DOI:10.1017/S135561771700100X] [PMID] []
9. Sosa-Ortiz AL, Acosta-Castillo I, Prince MJ. Epidemiology of dementias and Alzheimer's disease. Arch Med Res. 2012; 43(8):600-08. [DOI:10.1016/j.arcmed.2012.11.003] [PMID]
10. Li X, Kolltveit KM, Tronstad L, Olsen I. Systemic diseases caused by oral infection. Clin Microbiol Rev. 2000; 13(4):547-58. [DOI:10.1128/CMR.13.4.547] [PMID]
11. Borsa L, Dubois M, Sacco G, Lupi L. Analysis the Link between Periodontal Diseases and Alzheimer's Disease: A Systematic Review. Int J Environ Res Public Health. 2021; 18(17):1-14. [DOI:10.3390/ijerph18179312] [PMID] []
12. Botelho J, Lyra P, Proença L, Godinho C, Mendes JJ, Machado V. Relationship between blood and standard biochemistry levels with periodontitis in Parkinson's Disease patients: Data from the NHANES 2011-2012. J Pers Med. 2020; 25; 10(3):69. [DOI:10.3390/jpm10030069] [PMID] []
13. Sofiabadi M, Esmaeili MH, Mafi AM. Effects of morphine on spatial learning and memory in Healthy Rats and Streptozotocin Rat Model of Alzheimer's disease. J Sabzevar Univ Med Sci. 2019; 27(2):141-153. (full text in Persian)
14. Tomás Pereira I, Burwell RD. Using the spatial learning index to evaluate performance on the water maze. Behav Neurosci. 2015;129(4):533-9. [DOI:10.1037/bne0000078] [PMID] []
15. Samiee-Rad F. Sofiabadi M, Habibian Z, Gheibi N. Effects of the oral administration of silver nanoparticles on wound healing in male rats. Wound Practice Res. 2020; 28(1):8-16. [DOI:10.33235/wpr.28.1.8-16]
16. Nasri S, Rahimi M, Mozafari M. Effect of quercetin on learning and memory in STZ-induced diabetic rat. J Gorgan Univ Med Sci. 2015; 16 (4):34-41. (full text in Persian)
17. Akhtar A, Bishnoi M, Pilkhwal SS. Sodium orthovanadate improves learning and memory in intracerebroventricular-streptozotocin rat model of Alzheimer's disease through modulation of brain insulin resistance induced tau pathology. Brain Res Bull. 2020; 164: 83-97. [DOI:10.1016/j.brainresbull.2020.08.001] [PMID]
18. Breivik T, Opstad PK, Engstad R, Gundersen G, Gjermo P, Preus H. Soluble b-1,3/1,6-glucan from yeast inhibits experimental periodontal disease in Wistar rats. J Clin Periodontol. 2005; 32: 347-352. [DOI:10.1111/j.1600-051X.2005.00672.x] [PMID]
19. Ide M, Harris M, Stevens A, Sussams R, Hopkins V, Culliford D, et al. Periodontitis and Cognitive Decline in Alzheimer's Disease. PLoS ONE. 2016; 11(3):1-9. [DOI:10.1371/journal.pone.0151081] [PMID] []
20. Sparks SP, Steffen MJ, Smith C, Jicha G, Ebersole JL, Abner E, et al. Serum antibodies to periodontal pathogens are a risk factor for Alzheimer's disease. Alzheimers Dement. 2012; 8(3):196-203. [DOI:10.1016/j.jalz.2011.04.006] [PMID] []
21. Francisco BT, Miki TS, Filipe CM, Rui DP, Elizabeth S, Cristiane SF. Periodontitis and Alzheimer's Disease: A possible comorbidity between oral chronic inflammatory condition and neuroinflammation. Front Aging Neurosci. 2017; 9:327. [DOI:10.3389/fnagi.2017.00327] [PMID] []
22. Amber W, Eileen MC, Margaret G. Inflammation as a potential mediator for the association between periodontal disease and Alzheimer's disease. Neuropsychiatr Dis Treat. 2008; 4(5): 865-876. [DOI:10.2147/NDT.S3610] [PMID] []
23. Said-Sadier N, Sayegh B, Farah R, Abbas LA, Dweik R, Tang N, et al. Association between periodontal disease and cognitive impairment in adults. Int J Environ Res Public Health. 2023; 20(6):4707. [DOI:10.3390/ijerph20064707] [PMID] []
24. Kubota T, Maruyama S, Abe D, Tomita T, Morozumi T, Nakasone N, et al. Amyloid beta (A4) precursor protein expression in human periodontitis-affected gingival tissues. Arch Oral Biol. 2014; 59: 586-594. [DOI:10.1016/j.archoralbio.2014.03.004] [PMID]
25. Murakami S. Periodontal tissue regeneration by signalling molecule(s): What role does basic fibroblast growth factor (FGF-2) have in periodontal therapy? Periodontol. 2011; 56:188-208. [DOI:10.1111/j.1600-0757.2010.00365.x] [PMID]
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA

Ethics code: 1402

XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Sofiabadi M, Samiee F, Esmaeili M H. Effect of Experimental Alzheimer's disease on the Periodontal Polymorphonuclear (PMN), Eosinophils, Mast Cells, and Collagen Fibers and New Vascularis in Rat. J Ardabil Univ Med Sci 2023; 23 (2) : 6
URL: http://jarums.arums.ac.ir/article-1-2270-en.html
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 23, Issue 2 (summer 2023) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
Persian site map - English site map - Created in 0.16 seconds with 41 queries by YEKTAWEB 4623