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:: Volume 23, Issue 2 (summer 2023) ::
J Ardabil Univ Med Sci 2023, 23(2): 170-179 Back to browse issues page
Effect of Experimental Alzheimer's disease on the Periodontal Polymorphonuclear (PMN), Eosinophils, Mast Cells, and Collagen Fibers and New Vascularis in Rat
Mohammad Sofiabadi , Fateme Samiee , Mohammad Hossein Esmaeili *
Cellular and Molecular Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran , esmail66@yahoo.com
Abstract:   (586 Views)
Background & objectives: There is a tendency to increase the risk of dementia in patients with periodontitis, but the opposite, the role of Alzheimer's disease on periodontal disease is still unclear, so in this study, the effect of experimental Alzheimer's disease on periodontal inflammatory cells, collagen fibers and neovascularization was investigated in male rats.
Methods: In this experimental study, 16 Wistar male rats (230-250 grams) were randomly divided into 2 groups; control (saline) and streptozotocin 3 mg/kg (bilateral ICV injection, with a volume of 10 μl, in both groups). After 4 weeks of treatment, two groups were tested with the Morris water maze. Then the rats were killed by deep anesthesia and sampling from the papilla around the two central incisor teeth was done. Samples were fixed and the paraffin block was prepared, serial 5-micron slices were made with a microtome. After hematoxylin & eosin staining, the number of inflammatory cells (PMNs, eosinophils, and mast cells), angiogenesis, and fibroblasts were counted using a microscope (400×). Data were analyzed using SPSS 21 software and an independent T-test.
Results: The results showed that Alzheimer's disease causes an increase in periodontal inflammatory cells, collagen fibers and new vessels in the gums of mice, and the difference between these changes between the experimental and control groups was significant in all parameters (p<0.00).
Conclusion: According to these findings, Alzheimer's disease causes or aggravates inflammation and increases the rate of periodontal diseases in rat and may have the same effect in humans.
 
Article number: 6
Keywords: Alzheimer's Disease, Inflammatory Cells, Periodontal Disease, Collagen Fibers, Rat
Full-Text [PDF 467 kb]   (239 Downloads)    
Type of Study: article | Subject: دندانپزشکی
Received: 2023/04/15 | Accepted: 2023/06/27 | Published: 2023/08/30
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Sofiabadi M, Samiee F, Esmaeili M H. Effect of Experimental Alzheimer's disease on the Periodontal Polymorphonuclear (PMN), Eosinophils, Mast Cells, and Collagen Fibers and New Vascularis in Rat. J Ardabil Univ Med Sci 2023; 23 (2) : 6
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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 23, Issue 2 (summer 2023) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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