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:: Volume 21, Issue 4 (winter 2021) ::
J Ardabil Univ Med Sci 2021, 21(4): 388-401 Back to browse issues page
The Interaction Effect of Aerobic Exercise and Atorvastatin Consumption on the expression level of MFN1/2 and DRP1 in Hepatocytes of the Rat Liver with Type 2 Diabetes
Maryam Zolfali Pourfar , Farhad Rahmani Nia * , Parvin Farzanegi
Department of Sports Physiology, Faculty of Physical Education and Sports Sciences, University of Guilan, Rasht, Iran
Abstract:   (191 Views)
Background & objectives: Dynamic disorders of mitochondria cause the pathogenesis of many diseases, such as type 2 diabetes. Therefore, the aim of this study was to investigate the interactive effect of aerobic exercises and atorvastatin consumption on the expression of MFN1/2 and DRP1 in hepatocytes of rat liver with type 2 diabetes.
Methods: In this experimental study, 25 male rats were divided into 5 equal groups: diabetes, healthy control, persistence+diabetes, atorvastatin+diabetes, persistence+atorvastatin+ diabetes. Type 2 diabetes was induced by streptozotocin (STZ) in mice. The training groups performed the running program on the treadmill for eight weeks. Atorvastatin and atorvastatin-exercise groups received atorvastatin (10 mg/kg) by gavage. 48 hours after the last training session, the rats were dissected; their liver tissue was removed and immediately frozen in liquid nitrogen solution at a temperature of minus 80 ° C to measure MFN1/2 and DRP1. One-way analysis of variance and Tukey post hoc test were used for statistical analysis at a significance level of p<0.05.
Results: The results showed that induction of type 2 diabetes decreased the expression of MFN1/2 and increased DRP1 compared to the healthy group. After eight weeks of intervention, a significant increase was observed in the expression level of MFN1 (p<0.05), but this increase was not significant in MFN2 and there was no significant difference in the expression of factors between the groups. Also, after eight weeks, a significant decrease in DRP1 gene expression was observed (p<0.05). This decrease was significant in comparison with the combined groups compared to the patient group.
Conclusion: It is possible that a combination of aerobic exercises and atorvastatin may positively regulate the expression of genes related to mitochondrial dynamics in diabetes.
 
Article number: 3
Keywords: Aerobic Exercises, Atorvastatin, Mitochondrial Dynamics, Diabetes
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Type of Study: article | Subject: تربیت بدنی- فیزیولوژی ورزش
Received: 2022/06/12 | Accepted: 2022/08/3 | Published: 2021/12/31
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Zolfali Pourfar M, Rahmani Nia F, Farzanegi P. The Interaction Effect of Aerobic Exercise and Atorvastatin Consumption on the expression level of MFN1/2 and DRP1 in Hepatocytes of the Rat Liver with Type 2 Diabetes. J Ardabil Univ Med Sci 2021; 21 (4) :388-401
URL: http://jarums.arums.ac.ir/article-1-2161-en.html


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Volume 21, Issue 4 (winter 2021) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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