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RNA Editing and Its Application in Medicine
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Aida Nahumi    , Maryam Peymani , Hussein A Ghanimi , Asadollah Asadi , Arash Abdolmaleki * |
| Department of Biophysics, Faculty of Advanced Technologies, University of Mohaghegh Ardabili, Namin, Iran , Abdolmalekiarash1364@gmail.com |
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Abstract: (882 Views) |
Background & objectives: One of the functions of RNA editing is to change the RNA sequence without changing the genomic DNA sequence and changing the fate of cellular RNA. Therefore, studying the clinical application of RNA editing for targeted therapies is necessary.
Methods: All articles related to the subject of the study were searched in the Scopus,
PubMed/Medline, ISI Web of Knowledge, and Google Scholar database.
Results: The changes that occur within the RNA editing are A to I base replacement by adenosine deaminase (ADAR) on RNA and C to U replacement by the apolipoprotein B mRNA-editing enzyme, catalytic polypeptide1 (APOBEC1). Recently, the role of RNA editing in human diseases has been reported.
Conclusion: RNA editing can be used as a new strategy to identify new disease biomarkers and more personalized treatments for various diseases.
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Article number: 1 |
| Keywords: RNA Editing, ADAR Protein, Innate Immune Response, Cancer |
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Full-Text [PDF 1701 kb]
(415 Downloads)
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Type of Study: review article |
Subject:
Genetics and molecular medicine
Received: 2022/05/21 | Accepted: 2022/09/5 | Published: 2022/07/1
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