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:: Volume 21, Issue 2 (summer 2021) ::
J Ardabil Univ Med Sci 2021, 21(2): 201-213 Back to browse issues page
The Effects of Chronic Administration of Hydrogen Sulfide on Anxiety and Depression-like Behaviors in Streptozotocin Rat Model of Alzheimer’s Disease
Hashem Haghdopst , Mohammad Hossein Esmaeili * , Mohammad Sofiabadi , Pouria Solimany , Samira Esmaeili
Department of Physiology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
Abstract:   (218 Views)
Background & objectives: Alzheimer’s disease (AD) patients suffer from anxiety and depression. Sodium hydrosulfide (NaHS) can remit the depressive-like and anxiety-like behaviors induced by diabetes mellitus. We aimed to investigate the effects of chronic administration of hydrogen sulfide on depressive and anxiety-like behaviors in the Streptozotocin (STZ) rat model of AD.
Methods: Animals were divided into: Control, NaHS, and Alzheimer’s rats group include (STZ, STZ + Saline and STZ + NaHS groups) which were the Alzheimer’s rats and received Saline and NaHS (5.6 mg/kg per d) for 21 days. For induction of AD, STZ (3 mg/kg, 10 μl/injection site) was administered into the lateral ventricles. The behavioral consequences were assessed using plus maze, forced swim and sucrose preference tests.
Results: Our results showed that intracerebroventricular (i.c.v.) injection of STZ decreased the percentage of open arm time and entries, indicating anxiety-like effects. It also increased the duration of immobility time and decreased the percentage of sucrose preference indicating depression-like effects. Sodium hydrosulfide administration in STZ-treated rats increased the percentage of open arm time and entries, indicating anxiolytic-like effects. It also decreased the duration of immobility time and increased the percentage of sucrose preference, indicating antidepressant-like effects.
Conclusion: STZ administration can induce depression- and anxiety-like symptoms in rats, and Sodium hydrosulfide treatment, decreased the depression- and anxiety-like symptoms in STZ rat Model of AD, suggests that Sodium hydrosulfide can be useful in the treatment of affective disorders in AD patients.
Keywords: Alzheimer’s Disease, Sodium Hydrosulfide, Streptozotocin, Depression, Anxiety
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Type of Study: article | Subject: فیزیولوژی
Received: 2022/02/20 | Accepted: 2022/05/26 | Published: 2021/07/1
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Haghdopst H, Esmaeili M H, Sofiabadi M, Solimany P, Esmaeili S. The Effects of Chronic Administration of Hydrogen Sulfide on Anxiety and Depression-like Behaviors in Streptozotocin Rat Model of Alzheimer’s Disease. J Ardabil Univ Med Sci. 2021; 21 (2) :201-213
URL: http://jarums.arums.ac.ir/article-1-2089-en.html


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Volume 21, Issue 2 (summer 2021) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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