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The Effects of Chronic Administration of Hydrogen Sulfide on Anxiety and Depression-like Behaviors in Streptozotocin Rat Model of Alzheimer’s Disease
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Hashem Haghdopst    , Mohammad Hossein Esmaeili * , Mohammad Sofiabadi , Pouria Solimany , Samira Esmaeili |
| Department of Physiology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran , esmail66@yahoo.com |
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Abstract: (989 Views) |
Background & objectives: Alzheimer’s disease (AD) patients suffer from anxiety and depression. Sodium hydrosulfide (NaHS) can remit the depressive-like and anxiety-like behaviors induced by diabetes mellitus. We aimed to investigate the effects of chronic administration of hydrogen sulfide on depressive and anxiety-like behaviors in the Streptozotocin (STZ) rat model of AD.
Methods: Animals were divided into: Control, NaHS, and Alzheimer’s rats group include (STZ, STZ + Saline and STZ + NaHS groups) which were the Alzheimer’s rats and received Saline and NaHS (5.6 mg/kg per d) for 21 days. For induction of AD, STZ (3 mg/kg, 10 μl/injection site) was administered into the lateral ventricles. The behavioral consequences were assessed using plus maze, forced swim and sucrose preference tests.
Results: Our results showed that intracerebroventricular (i.c.v.) injection of STZ decreased the percentage of open arm time and entries, indicating anxiety-like effects. It also increased the duration of immobility time and decreased the percentage of sucrose preference indicating depression-like effects. Sodium hydrosulfide administration in STZ-treated rats increased the percentage of open arm time and entries, indicating anxiolytic-like effects. It also decreased the duration of immobility time and increased the percentage of sucrose preference, indicating antidepressant-like effects.
Conclusion: STZ administration can induce depression- and anxiety-like symptoms in rats, and Sodium hydrosulfide treatment, decreased the depression- and anxiety-like symptoms in STZ rat Model of AD, suggests that Sodium hydrosulfide can be useful in the treatment of affective disorders in AD patients. |
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| Keywords: Alzheimer’s Disease, Sodium Hydrosulfide, Streptozotocin, Depression, Anxiety |
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Full-Text [PDF 715 kb]
(392 Downloads)
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Type of Study: article |
Subject:
Physiology
Received: 2022/02/20 | Accepted: 2022/05/26 | Published: 2021/07/1
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