Background & Objectives: Acne vulgaris is a chronic inflammation of pilosebaceous units. In sever forms it may lead to major scars on the face and trunk, and significant face and trunk scarring, and psychological disorders. Antiandrogen therapy can be used as a suitable and effective remedy for female acne. Furthermore, they can treat, accompanying androgenic problems. Also, there is no under consideration drug resistance against androgens. The aim of this study is to compare the therapeutic effects of flutamide and doxycycline in moderate acne in females .

  Methods: This current study is a randomized and blind evaluation trial. 62 female patients participated at this study. They were divided in two groups (case and control). Case group was received 250 mg/day flutamide, control group 100 mg/day doycycline. Both groups also received topical solution of clindamicin 1% twice daily. The length of study was six months .

  At first visit and the end of the second month of study liver function were tested for the case group patients. Evaluation of resolution in lesions was performed by another physician every two months of therapy. The probable side effects of drugs were recorded. Data were analyzed with SPSS16 software using statistical tests and p ≤ 0.05 considered as significant

  Results: The mean of patients age was 19.27 ± 3.55 years, and the difference was not found to be statistically significant in two groups. Number of comdeons on face was found to be statistically decreased in flutamide group (p<0.0001). Mean of ASI was found to be statistically decreased in flutamide group (p<0.002). In flutamide group the levels of satisfaction was higher than that of other group. Both medications well tolerated by participiants. Only two patients in flutamide group had lightly elevated serum Alkalin phosphatase .

  Conclusion: The results of our study showed that flutamide (250 mg /day) is more effective than doxycycline (100 mg/day) in treatment of acne. Satisfaction of participants in flutamide group was higher than those in doxycycline group. In both groups side effects of drugs were insignificant, but using of flutamide in acne treatment needs laboratory considerations .