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:: Volume 20, Issue 3 (autumn 2020) ::
J Ardabil Univ Med Sci 2020, 20(3): 296-306 Back to browse issues page
Protective Effect of Berberine Chloride and Aerobic Training on Liver Nrf2/HO-1 Pathway and PPARγ in Streptozotocin-induced Diabetic Rats
Mozhgan Sahraei , Ahmad Abdi * , Hamed Jalal
Department of Exercise Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran
Abstract:   (1318 Views)
Background & objectives: The increased incidence of metabolic diseases (e.g., diabetes and obesity) has seriously affected human health and life safety worldwide. It is of great significance to find effective drugs from natural compounds and exercise to treat metabolic diseases. The aim of this study was to evaluate the effect of berberine chloride with aerobic training on Liver Gene Expression Nrf2, HO-1 and PPARγ in Streptozotocin (STZ)-induced diabetic rats.
 Methods: In this experimental study,  32 male Wistar rats were randomly divided into four groups (n=8): Diabetes (DM), Diabetes-Berberine (BDM), Diabetes-Aerobic Training (TDM), Diabetes-Aerobic Training -Berberine (TBDM). Diabetes was induced by injection of STZ in male rats. Berberine chloride (30 mg/kg/day) were administered orally, by gavage, once a day. Training groups have performed a progressive aerobic running program (at 10-18 m/min, 10-40 min/day, and 5 days/week) on a motor-driven treadmill for six weeks.
Results: There was a significant increase in Nrf2 and HO-1 expression in BDM in BDM (p=0.027 and p=0.038, respectively), TDM (p=0.022 and p=0.028, respectively) and TBDM (p=0.000 and p=0.000, respectively). This increase was also observed in TBDM groups compared to BDM (p=0.034 and p=0.034, respectively) and TDM (p=0.043 and p=0.046, respectively). PPARγ was significantly increased in TDM (p=0.046) and TBDM (p=0.001) groups.
Conclusions: Berberine chloride combination with exercise may possibly inhibit STZ-induced liver damage through up-regulating the Nrf2/HO-1 pathway and PPARγ.
Keywords: Exercise, Berberine Chloride, Nrf2, PPARγ, Diabetes
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Type of Study: article | Subject: تربیت بدنی- فیزیولوژی ورزش
Received: 2021/01/28 | Accepted: 2021/04/19 | Published: 2021/05/10
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Sahraei M, Abdi A, Jalal H. Protective Effect of Berberine Chloride and Aerobic Training on Liver Nrf2/HO-1 Pathway and PPARγ in Streptozotocin-induced Diabetic Rats. J Ardabil Univ Med Sci. 2020; 20 (3) :296-306
URL: http://jarums.arums.ac.ir/article-1-1981-en.html

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Volume 20, Issue 3 (autumn 2020) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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