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:: Volume 20, Issue 3 (autumn 2020) ::
J Ardabil Univ Med Sci 2020, 20(3): 361-371 Back to browse issues page
The Effect of Moderate-Intensity Endurance Training on the Expression Level of Angiogenesis Factors and Cardiac Oxidative Stress in Rats
Farnaz Seyfi Askshahr * , Mojdeh Khajehlandi
Department of Exercise Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran
Abstract:   (1472 Views)
Background & Objectives: Based on the probably positive role of exercise on total oxidative status (TOS) and total antioxidant system (TAS) and their effect on the process of angiogenesis, the aim of the current study was to evaluate the effect of one course of moderate-intensity endurance training on the gene expression level of vascular endothelial growth factor-B (VEGF-B) and angiopoietin-1(ANGPT-1) and TAS and TOS status in cardiac tissue of male rats.
Methods: In this study, 20 male Wistar rats were divided into two equal groups as follows:   1-training group and 2- control group: no sports activities were performed on them. Rats in the training group performed moderate endurance training for 6 weeks and 5 sessions per week from the twelfth week of life. Twenty-four hours after the last training session, heart tissue samples were extracted to measure gene expression levels of VEGF-B and ANGPT-1 and the TAS and TOS status in heart tissues. T-test with the statistical level of (p˂0.05) was used for between groups comparison.
Results:­ Findings showed that after six weeks of endurance training, the expression level of ANGPT-1 and VEGF-B and the amount of TAS in the exercise group significantly increased (p=0.001) and the amount of TOS significantly decreased compared to the control group (p=0.008).
Conclusion: According to the results of the present study, it seems that moderate-intensity endurance training can be effective in preventing cardiovascular disease by increasing factors involving in angiogenesis, improving TAS and reducing TOS in heart tissue of rats.
Keywords: Moderate Intensity Endurance Training, Heart, Angiogenesis, Oxidative Stress
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Type of Study: article | Subject: فیزیولوژی
Received: 2020/11/29 | Accepted: 2021/10/2 | Published: 2021/10/2
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Seyfi Askshahr F, Khajehlandi M. The Effect of Moderate-Intensity Endurance Training on the Expression Level of Angiogenesis Factors and Cardiac Oxidative Stress in Rats. J Ardabil Univ Med Sci 2020; 20 (3) :361-371
URL: http://jarums.arums.ac.ir/article-1-1953-en.html

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Volume 20, Issue 3 (autumn 2020) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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