[Home ] [Archive]   [ فارسی ]  
:: Main In Press Current Issue All Issues Search register ::
Main Menu
Home::
Journal Information::
Editorial Board::
Articles archive::
For Authors::
For Reviewers::
Editorial Policy::
Registration::
Contact us::
::
..
Indexing

 

 

 

 

 
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Creative commons

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

..
:: Volume 18, Issue 1 (spring 2018) ::
J Ardabil Univ Med Sci 2018, 18(1): 43-51 Back to browse issues page
Evaluation of Ultrasonography Results in Terms of Involvement of Lymph Nodes before Thyroidectomy and Its Comparison with Pathologic Results after Thyroidectomy in Non-Medullary Thyroid Carcinoma Patients
Shahriar Hashemzadeh , Davood Imani * , Reza Javad Rashid , Mohammad Kazem Tarzamani , Sajjad Pourasghary
Department of General Surgery, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran , imanidavoud96@gmail.com
Abstract:   (29632 Views)
Background & objectives: 10 year survival rates for thyroid cancer is about 90%, but papillary thyroid cancer often spread to regional lymph nodes resulting in survival rate falls below 90%. In patients with thyroid cancer, cervical lymph node metastasis risk is about 20 to 50 percent. The aim of this study was to evaluate the association between ultrasound results and the involvement of lymph nodes before thyroidectomy and compare it with the pathologic response after thyroidectomy in patients with non-medullary thyroid cancer.
Methods: 60 patients with thyroid cancer were randomly selected and entered into the study. Ultrasonographic examination of cervical lymph nodes was performed by two radiologists using an ultrasound machine in all patients diagnosed with thyroid cancer. Patients underwent total thyroidectomy and neck lymph node dissection by surgeon.
Results: In papillary thyroid cancer, there was a significant relationship between ultrasonographic results and pathologic outcomes in determining the presence of cervical lymph node metastasis before thyroidectomy. And also, there was a significant relationship between the results of ultrasonography and pathologic findings in determining the location of affected lymph nodes.
Conclusion: Compared to histological examination, ultrasonography can be a useful tool in determining the location of affected cervical lymph node in thyroid cancers before surgery.
Keywords: Ultrasonography, Thyroidectomy, Metastasis, Thyroid Cancer
Full-Text [PDF 129 kb]   (4007 Downloads)    
Type of Study: article | Subject: General
Received: 2017/09/21 | Accepted: 2018/01/20 | Published: 2018/03/29
References
1. Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, et al. Management guidelines for patients with thyroid nodules and differentiated thyroid cancer: The American Thyroid Association Guidelines Taskforce. Thyroid. 2006 Feb;16(2):109-42. [DOI:10.1089/thy.2006.16.109]
2. Lundgren CI, Hall P, Dickman PW, Zedenius J. Clinically significant prognostic factors for differentiated thyroid carcinoma. Cancer. 2006 Feb;106(3):524-31. [DOI:10.1002/cncr.21653]
3. Moo TA, McGill J, Allendorf J, Lee J, Fahey T, Zarnegar R. Impact of prophylactic central neck lymph node dissection on early recurrence in papillary thyroid carcinoma. World J Surg. 2010 Jun;34(6):1187-91. [DOI:10.1007/s00268-010-0418-3]
4. Hughes DT, White ML, Miller BS, Gauger PG, Burney RE, Doherty GM. Influence of prophylactic central lymph node dissection on postoperative thyroglobulin levels and radioiodine treatment in papillary thyroid cancer. Surgery. 2010 Dec;148(6):1100-7. [DOI:10.1016/j.surg.2010.09.019]
5. Tisell L-E, Nilsson B, Mölne J, Hansson G, Fjälling M, Jansson S, et al. Improved survival of patients with papillary thyroid cancer after surgical microdissection. World J Surg. 1996 Sep;20(7):854-9. [DOI:10.1007/s002689900130]
6. Ito Y, Tomoda C, Uruno T, Takamura Y, Miya A, Kobayashi K, et al. Clinical significance of metastasis to the central compartment from papillary microcarcinoma of the thyroid. World J Surg. 2006 Jan;30(1):91-9. [DOI:10.1007/s00268-005-0113-y]
7. Marshall CL, Lee JE, Xing Y, Perrier ND, Edeiken BS, Evans DB, et al. Routine pre-operative ultrasonography for papillary thyroid cancer: effects on cervical recurrence. Surgery. 2009 Dec;146(6):1063-72. [DOI:10.1016/j.surg.2009.09.027]
8. Mazzaferri EL, Jhiang SM. Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer. Am J Med. 1994 Nov;97(5):418-28. [DOI:10.1016/0002-9343(94)90321-2]
9. Kang BC, Roh J-L, Lee JH, Cho K-J, Gong G, Choi S-H, et al. Candidates for limited lateral neck dissection among patients with metastatic papillary thyroid carcinoma. World J Surg. 2014 Apr;38(4):863-71. [DOI:10.1007/s00268-013-2361-6]
10. Kouvaraki MA, Shapiro SE, Fornage BD, Edeiken-Monro BS, Sherman SI, Vassilopoulou-Sellin R, et al. Role of preoperative ultrasonography in the surgical management of patients with thyroid cancer. Surgery. 2003 Dec;134(6):946-54. [DOI:10.1016/S0039-6060(03)00424-0]
11. Stulak JM, Grant CS, Farley DR, Thompson GB, Van Heerden JA, Hay ID, et al. Value of preoperative ultrasonography in the surgical management of initial and reoperative papillary thyroid cancer. Arch Surg. 2006 May;141(5):489-96. [DOI:10.1001/archsurg.141.5.489]
12. Ahn D, Sohn JH, Park JY. Surgical complications and recurrence after central neck dissection in cN0 papillary thyroid carcinoma. Auris Nasus Larynx. 2014 Feb;41(1):63-8. [DOI:10.1016/j.anl.2013.06.002]
13. Chung J, Kim EK, Lim H, Son EJ, Yoon JH, Youk JH, et al. Optimal indication of thyroglobulin measurement in fine‐needle aspiration for detecting lateral metastatic lymph nodes in patients with papillary thyroid carcinoma. Head & neck. 2013 Aug;36(6):795-801. [DOI:10.1002/hed.23371]
14. Elfenbein DM, Scheri RP, Roman S, Sosa JA. Detection and management of cervical lymph nodes in papillary thyroid cancer. Expert Rev Endocrinol Metab. 2014 Jan;8(4):365-78. [DOI:10.1586/17446651.2013.811839]
15. Kim E, Park JS, Son K-R, Kim J-h, Jeon SJ, Na DG. Preoperative diagnosis of cervical metastatic lymph nodes in papillary thyroid carcinoma: comparison of ultrasound, computed tomography, and combined ultrasound with computed tomography. Thyroid. 2008 Apr;18(4):411-8. [DOI:10.1089/thy.2007.0269]
16. Tang K-T, Lee C-H. BRAF mutation in papillary thyroid carcinoma: pathogenic role and clinical implications. J Chin Med Assoc. 2010 Mar;73(3):113-28. [DOI:10.1016/S1726-4901(10)70025-3]
17. Scheumann GF, Gimm O, Wegener G, Hundeshagen H, Dralle H. Prognostic significance and surgical management of locoregional lymph node metastases in papillary thyroid cancer. World J Surg. 1994 Jul;18(4):559-67. [DOI:10.1007/BF00353765]
18. Qubain SW, Nakano S, Baba M, Takao S, Aikou T. Distribution of lymph node micrometastasis in pN0 well-differentiated thyroid carcinoma. Surgery. 2002 Mar;131(3):249-56. [DOI:10.1067/msy.2002.120657]
19. Shimamoto K, Satake H, Sawaki A, Ishigaki T, Funahashi H, Imai T. Preoperative staging of thyroid papillary carcinoma with ultrasonography. Eur J Radiol. 1998 Nov;29(1):4-10. [DOI:10.1016/S0720-048X(97)00184-8]
20. Sipos JA. Rationale for the Evaluation of Cervical Lymph Nodes in the Setting of Thyroid Cancer. Advanced Thyroid and Parathyroid Ultrasound: Springer; 2017 Mar. 197-206.
21. Hwang HS, Orloff LA. Efficacy of preoperative neck ultrasound in the detection of cervical lymph node metastasis from thyroid cancer. Laryngoscope. 2011 Mar;121(3):487-91. [DOI:10.1002/lary.21227]
22. Pellegriti G, Frasca F, Regalbuto C, Squatrito S, Vigneri R. Worldwide Increasing Incidence of Thyroid Cancer: Update on Epidemiology and Risk Factors. J Cancer Epidemiol. 2013;2013:1-10. [DOI:10.1155/2013/965212]
23. Ron E, Lubin JH, Shore RE, Mabuchi K, Modan B, Pottern LM, et al. Thyroid cancer after exposure to external radiation: a pooled analysis of seven studies. Radiation research. 1995 Mr;141(3):259-77.
24. Ito Y, Tomoda C, Uruno T, Takamura Y, Miya A, Kobayashi K, et al. Preoperative ultrasonographic examination for lymph node metastasis: usefulness when designing lymph node dissection for papillary microcarcinoma of the thyroid. World J Surg. 2004 May;28(5):498-501. [DOI:10.1007/s00268-004-7192-z]
25. Noguchi S, Noguchi A, Murakami N. Papillary carcinoma of the thyroid I. Developing pattern of metastasis. Cancer. 1970 Nov;26(5):1053-60. https://doi.org/10.1002/1097-0142(197011)26:5<1053::AID-CNCR2820260513>3.0.CO;2-X [DOI:10.1002/1097-0142(197011)26:53.0.CO;2-X]
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Hashemzadeh S, Imani D, Javad Rashid R, Tarzamani M K, Pourasghary S. Evaluation of Ultrasonography Results in Terms of Involvement of Lymph Nodes before Thyroidectomy and Its Comparison with Pathologic Results after Thyroidectomy in Non-Medullary Thyroid Carcinoma Patients . J Ardabil Univ Med Sci 2018; 18 (1) :43-51
URL: http://jarums.arums.ac.ir/article-1-1525-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 18, Issue 1 (spring 2018) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
Persian site map - English site map - Created in 0.16 seconds with 41 queries by YEKTAWEB 4623