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J Ardabil Univ Med Sci 2018, 18(1): 91-107 Back to browse issues page
Study of Chromosomal Abnormalities in Couples with Recurrent Spontaneous Abortions (RSA) in Ardabil Province
Ziba Jahani , Seyyed saeid Hosseini Asl , Homa Akhavan
Laboratory of Medical Genetics, Imam Khomeini Hospital, Ardabil University of Medical Sciences, Ardabil, Iran.
Abstract:   (6750 Views)
Background & objectives: The spontaneous abortion, loss of the fetus until the twentieth week of pregnancy, is one of the most common medical problems in reproductive age. Approximately 15 to 20 percent of all clinically recognized pregnancies lead to abortion. Failure in pregnancy involves economic costs, physical and mental problems for the family and the society. Recurrent spontaneous abortion is a multifactorial phenomenon and this study analyzed chromosomal abnormalities and the prevalence of consanguineous marriages in parents with recurrent spontaneous abortions in Ardabil province.
Methods: A total of 350 patients with at least two spontaneous abortions were analyzed using GTG-banding cytogenetic technique.
Results:  Parental chromosomal abnormalities were found in 18 cases (10.28% of couples). Most of abnormalities were structural (72.2%). chromosomal aberrations were found in 10 (55.6%) females and 8 (44.4%) males. Translocations were the most common chromosomal abnormalities (55.6 %) diagnosed in this study. Also, there was a significant correlation between recurrent spontaneous abortion due to consanguineous marriage and chromosomal abnormalities (p<0.05).
Conclusion: According to the significant correlation between recurrent spontaneous abortion and chromosomal abnormalities in this study and previous studies, and also the high rate of consanguineous marriages in Ardabil province population, analysis of chromosomal abnormalities is necessary after genetic counseling for both parents with recurrent spontaneous abortions.
Keywords: Recurrent Spontaneous Abortion; Chromosomal Abnormalities; Consanguineous
Keywords: Ardabil, GTG- Banding Method
Full-Text [PDF 372 kb]   (12315 Downloads)    
Type of Study: article | Subject: General
Received: 2017/08/23 | Accepted: 2018/01/20 | Published: 2018/03/29
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Jahani Z, Hosseini Asl S S, Akhavan H. Study of Chromosomal Abnormalities in Couples with Recurrent Spontaneous Abortions (RSA) in Ardabil Province . J Ardabil Univ Med Sci 2018; 18 (1) :91-107
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Volume 18, Issue 1 (spring 2018) Back to browse issues page
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