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Protective Effect of L-Carnitine on the Sperm Parameters of Adult Mice Treated with Ciprofloxacin
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Mina Kiani *   , Paria Parto |
| Department of Biology ,School of sciences, Razi University,Kermanshah, Iran , minakiani335@gmail.com |
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Abstract: (6789 Views) |
Background & objectives: The present study examined the gonadotoxic effects of ciprofloxacin antibiotics and protective effects of L-carnitine.
Methods: In this study, 20 NMRI mice were divided into four groups: control, ciprofloxacin, L-carnitine, L-carnitine-ciprofloxacin (each group included 5 animals). The control group received normal saline, the treatment group 1 received 12.5 mg/kg ciprofloxacin, the treatment group 2 received 100 mg/kg L- carnitine and the treatment group 3 received 100 mg/kg L- carnitine and 12.5 mg / kg ciprofloxacin simultaneously. All animals were treated by intraperitoneal administration for 15 days. Testis and epididymis were collected to evaluate sperm parameters (sperm count, motility, morphology and viability).
Results: In the ciprofloxacin group, a significant decrease in sperm count, sperm viability, sperm motility, progressive sperm motility and normal sperm as well as a significant increase in rotating sperm motility, sperm without movement, head and tail abnormalities were observed (p≤0.05). A significant increase in sperm count, sperm survival, motility and progressive sperm motility, normal sperm and a significant decrease in rotating sperm motility, sperm without movement and head abnormalities in the L-carnitine-ciprofloxacin group were observed (p≤0.05); however, the reduction in tail abnormalities of sperm was not significant.
Conclusion: L-carnitine improves sperm parameters in the adult mice treated with ciprofloxacin. |
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| Keywords: L- Carnitine, Ciprofloxacin, Sperm Parameters, Mice |
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Full-Text [PDF 1222 kb]
(2837 Downloads)
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Type of Study: article |
Subject:
General
Received: 2017/04/19 | Accepted: 2017/08/21 | Published: 2017/12/31
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