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:: Volume 17, Issue 1 (spring 2017) ::
J Ardabil Univ Med Sci 2017, 17(1): 113-121 Back to browse issues page
Cytogenetic Study of 100 Couples with Reproductive Failure by GTG-Banding Method in the Northwest of Iran
Rana Alizadeh Hajikhajehlu
Abstract:   (6509 Views)

Background & Objectives: Infertility (abortion & stillbirth) is one of the most common medical problems during pregnancy. Approximately 10-15% of all clinically recognized pregnancies are lost before the birth. Pregnancy loss is a multifactorial phenomenon. This study was an attempt to analysis the cytogenetic abnormalities of the parents with frequent spontaneous abortion and stillbirth.

Methods: In this study, the samples were analyzed by GTG-banding technique.

Results: From a total of 200 reviewed blood samples, 188 persons (94%) had natural karyotype and 12 persons (6%) had chromosomal abnormalities. Chromosomal aberrations were found in 5 (2.5%) females and 7 (3.5%) males. The prevalence of chromosomal abnormalities was as follows: 5(41.6%) pericentric inversion of chromosome 9, 3 (25%) polymorphism 15p+, 1(8.3%) translocation, 1 (8.3%) polymorphism 15ps+, 1 (8.3%) polymorphism 1qh+ and 1 (8.3%) unknown chromophil band on the short arm of chromosome 21.

Conclusion: Chromosomal analysis is an important etiological investigation in couples with recurrent spontaneous abortions and stillbirth, and genetic counseling helps to make a correct decision on further options of reproduction.

Keywords: Chromosomal Abnormalities, Recurrent Spontaneous Abortion, Stillbirth
Full-Text [PDF 143 kb]   (2957 Downloads)    
Type of Study: article | Subject: General
Received: 2016/08/25 | Accepted: 2017/02/18 | Published: 2017/03/30
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Alizadeh Hajikhajehlu R. Cytogenetic Study of 100 Couples with Reproductive Failure by GTG-Banding Method in the Northwest of Iran . J Ardabil Univ Med Sci 2017; 17 (1) :113-121
URL: http://jarums.arums.ac.ir/article-1-1321-en.html

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Volume 17, Issue 1 (spring 2017) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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