|
|
|
 |
Search published articles |
 |
|
Showing 4 results for Hasanpour
Alireza Mohammadzadeh, Farshad Tofigi, Hasanpour Hasanpour, Khatere Isazadehfar,
Volume 16, Issue 1 (spring 2016)
Abstract
Background & objectives: Cardiac arrhythmia after CABG surgery is a common complication which results in other side effects. Therapeutic effect of prophylactic magnesium administration is controversial and there are many different ideas in this case. The aim of this study was to evaluate the therapeutic effects of magnesium in reducing cardiac arrhythmia after CABG.
Methods: The clinical trial enrolled 140 patients undergoing CABG. Based on the initial blood levels of magnesium, patients were divided into two groups, one group with low serum magnesium and the other group with normal one. The low serum magnesium group treated with magnesium preoperatively and had normal serum magnesium level before operation. Postoperatively, both groups were randomly divided into two sub-groups, one receiving 2 gr. of magnesium sulfate and the other group received placebo. Both groups monitored for occurrence of arrhythmia in the ICU – OH for 3 days. Data were analyzed with statistical methods. P value of <0.05 was considered statistically significant.
Results: The results showed that the occurrence of arrhythmia in any of the sub-groups was not significantly different from each other (p> 0.05). There was no significant relationship between blood levels of magnesium and arrhythmia at different days (p> 0.05).
Conclusions: Blood level of magnesium and prophylactic magnesium administration have not effect on reducing arrhythmia after CABG surgery. The highest incidence of arrhythmias happened in the hypomagnesium group without prophylaxis on the third day after surgery, but this difference was not statistically significant.
Faranak Hasanpour, Kamaleddin , Hamidi , Saber Zahri, Saeeid Latifi Navid ,
Volume 17, Issue 2 (summer 2017)
Abstract
Background & Objectives: Breast cancer is one of the most common cancers of women in the world. Apoptotic pathway is one of the most important pathways to deal with cell damage, especially cancer, which is usually blocked in this disease. One of the main enzymes to set up this pathway is JNK (1,2,3α,3β), which is activated by cellular stress.
Methods: In this study, breast cancer cells with the origin of MCF-7 cell lines were cultured in RPMI medium using 10%fetal bovine serum.Then , they were subjected to heat (42 & 45 ̊ C) for 1,2,4,6 and 8 hours under X-ray and γ-ray radiations for 1,2,3 and 4 hours as well. Their viability and enzyme level were evaluated by MTT and ELISA tests, respectively.
Results: The obtained results showed that abiotic stresses including heat and radiations resulted in JNK level increase and recovery of apoptosis pathway function in breast cancer cells. In addition, they led to decreased of cell viability and increase of JNK level depending on the duration and kind of stress.
Conclusion: The results in this study showed abiotic stress directly affected the JNK level. Increase of this enzyme in the cell resulted in activity of JNK apoptosis pathway. We hope to find methods to help to cancer treatment by means of more studies on JNK enzyme and relevant pathways.
Faranak Hasanpour, Saber Zahri, Arash Abdolmaleki, Asadolah Asadi,
Volume 24, Issue 3 (Autumn 2024)
Abstract
Background: Tissue engineering, by designing biological scaffolds and imitating the extracellular environment, helps the growth and proliferation of cells and plays a key role in replacing and repairing damaged tissues. In recent years, the addition of nanoparticles, such as carbon quantum dots, to biological scaffolds has received attention. In this research, the synthesis of polycaprolactone scaffolds containing carbon quantum dots and the investigation of biocompatibility effects and their protection have been discussed.
Methods: Carbon quantum dots were synthesized using the pyrolysis method, and polymer scaffolds containing carbon quantum dots were prepared by the electrospinning method. The physical and chemical properties of the scaffold were evaluated by scanning electron microscopy and FTIR spectroscopy. The scaffolds' biocompatibility and antioxidant properties were measured by the MTT method.
Results: Examination of the morphology and chemical showed the appropriate porosity of the scaffold containing carbon quantum dots. The MTT assay significantly enhanced stem cell viability on scaffolds incorporating carbon quantum dots. Furthermore, these scaffolds exhibited a significant protective effect against oxidative stress.
Conclusion: This study showed that the polycaprolactone scaffold containing carbon quantum dots, with high biocompatibility and suitable antioxidant properties, provides an effective substrate for tissue engineering and cell protection under oxidative stress conditions.
Saghar Jafari-Ramedani, Fereshteh Hasanpour, Alireza Mohammadnia, Farzad Khademi, Aida Alinezhad,
Volume 24, Issue 3 (Autumn 2024)
Abstract
Background: The Gram-negative pathogen Pseudomonas aeruginosa (P. aeruginosa) is a common cause of hospital-acquired infections. This bacterium is continuously increasing its resistance to commonly used antimicrobial drugs, posing significant challenges for clinical treatment. Therefore, this study aimed to investigate the trend of antibiotic resistance in P. aeruginosa from 2019 to 2023 in hospitals in Ardabil city.
Methods: This cross-sectional descriptive study utilized 200 clinical isolates of P. aeruginosa obtained from urine, respiratory, wound, blood, and cerebrospinal fluid samples of patients who visited Ardabil hospitals between June 2019 and May 2023. The sensitivity and resistance of P. aeruginosa isolates to antibiotics-including piperacillin, piperacillin / tazobactam, ceftazidime, cefepime, aztreonam, imipenem, meropenem, amikacin, tobramycin, netilmicin, ciprofloxacin, ofloxacin, norfloxacin, levofloxacin, and colistin-were assessed using the disk diffusion and agar dilution methods.
Results: Over a period of 4 years, the resistance of P. aeruginosa to various antibiotics was observed as follows: piperacillin 45.5%, piperacillin/tazobactam 31%, ceftazidime 44%, cefepime 46%, aztreonam 12%, imipenem 67.5%, meropenem 52%, amikacin 43%, tobramycin 45.5%, netilmicin 39.2%, ciprofloxacin 55.5%, ofloxacin 62%, norfloxacin 53.5%, levofloxacin 55.5%, and colistin 9%. It is worth mentioning that the trend of antibiotic resistance in P. aeruginosa to all tested antibiotics increased during the first and second years, decreased in the third year, and then experienced a significant increase again in the fourth year. Throughout this period, the emergence of multidrug-resistant (MDR) strains of P. aeruginosa has also been on the rise.
Conclusion: The present study confirmed that the overall trend of resistance to various antibiotics among P. aeruginosa strains isolated from patients in Ardabil is on the rise.
|
|
.png)
.png)
