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Showing 2 results for Asadollahi
Elham Jannati , Maliheh Asadollahi , Hadi Peeri Doghaheh , Mohsen Arzanlou ,
Volume 14, Issue 2 (summer 2014)
Abstract
Background and Objectives: Group B streptococci (GBS) are the major cause of neonatal and maternal infections. They are susceptible to penicillin, ampicillin and first-generation cephalosporins. However, resistance to other antibiotics such as erythromycin and clindamycin is common among GBS strains. The aim of this study was to evaluate the antimicrobial activity of allicin against colonizing GBS strains in vitro. Methods: Garlic extract was prepared and allicin was purified using semi-preparative HPLC procedure. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of allicin were determined for 52 GBS strains using microdilution method in Todd Hewitt broth medium. Results: MIC of allicin was 64-128 µg/mL (MIC90 = 128) and MBC of allicin was 128 to 512µg/mL (MBC90 = 256) for GBS strains. Conclusion: The results of this study showed that allicin can inhibit growth of GBS in vitro. Further studies on allicin might be worthy of evaluation as a therapeutic agent in treatment of GBS infections.
Parinaz Tabibvand, Somayah Asadollahi, Masoomeh Dadkhah,
Volume 24, Issue 3 (Autumn 2024)
Abstract
Alzheimer's disease is a progressive, incessant and neurodegenerative disorder that affects large areas of the cerebral cortex and hippocampus. Abnormalities first involve the frontal and temporal lobes in the brain tissue and then slowly reach other areas of the neocortex. It seems that Alzheimer's patients who participated in sports activities had an increase in blood flow, hippocampal volume and improved neurogenesis. In this study, we provide an overview of the positive effects of exercise on the biomarkers of this challenging disease. In this study, PubMed, Google Scholar, and SID.IR databases were searched with the keywords "Alzheimer, Resistance Training, Endurance Training, Biomarker" between the years 2000 and 2024. The results of the studies indicate that exercise can be a non-pharmacological strategy to prevent or delay the decline of the cognitive power of the brain. Exercise also plays an effective role in changes in plasma biomarkers associated with Alzheimer's and cognitive impairment associated with the disease. Among the changes created following sports activity, we can mention the increase in the expression of neurotrophic factors in the brain, inhibition of oxidative stress, and angiogenesis, which leads to an increase in blood supply to the hippocampus tissue.
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