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Effect of the Injection Speed of Streptokinase in Patients with Acute MI Admitted to the Cardiac Intensive Care Section of Imam Khomeiny Hospital in Ardabil 2011-2012
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B Zamani   , M Azari * , A Hosseinian , A ShokrDargahy , A Mardi , Sh Azari |
| , m.azari2010@yahoo.com |
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Abstract: (9174 Views) |
Background & objectives: Myocardial infarction (MI) isone of the most commonly heart diseases in all countries with the mortality rate of about 30%. Reperfusion of blocked coronary arteries plays an important role in reducing mortality and enhancing the quality of life of patients after acute MI.
Methods: This clinical trial is to compare the efficacy of streptokinase administered intravenously in a two slow and accelerated groups: control group (slow intravenous infusion during 1 hour) and case group (half-hour accelerated intravenous infusion of streptokinase) with the sample size of 100 patients (divided randomly to 50 patients in each group). The data tool was a questionnaire, included the collected ECG changes before and after echocardiography and laboratory tests of patients. Data analyzed with SPSS software using chi-square test.
Results:After reperfusion of the coronary artery, in the both case and control groups, elevation of ST segment has decreased statistically in two groups (60% and 84%, respectively). The complications rate following injection of SK in both case and control groups were 46% and 56%, respectively. The fraction in which 30% and 38% belong to cardiac complications, 32% and 22% to allergic symptoms and hematologic effects were 32% and 22%, in two groups, respectively and there was no statistically significant difference between two groups.
Conclusion:According to the results of this study the accelerated (30 minutes) SK infusion can be fruitful for improving coronary reperfusion in patients with MI. |
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| Keywords: Myocardial Infarction, Intravenous Streptokinase, Injection Speed |
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Full-Text [PDF 130 kb]
(2745 Downloads)
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Type of Study: article |
Received: 2014/06/1 | Accepted: 2015/03/1 | Published: 2015/07/1
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