Background & objectives: Warts are common dermatological disorder which are difficult to treat and usually relapse. In this study the efficacy of topical %5 5- fluorouracil was compared with conventional cryotherapy in treatment of plantar Warts.

 Methods: In a clinical trial study, 50 patients clinically diagnosed as warts were divided in to two groups. 25 patients were treated with topical 5% 5- fluorouracil while the other 25 were treated with cryotherapy. After treatment, patients were followed for 6 months from the viewpoints of treatment complication, efficacy and relapse rate.�

 Results: It was observed that treating period in cryotherapy was short but 5F-U therapy needed longer time. Initially in 5-FU group 52% of patient had good response, 36%moderate response and in 12% no response was observed there is no significant difference in view of sex in this group (p=51%) and in cryotherapy group 60% of patients had good response, 28% moderate response and in 12% no response was observed like wise there was no significant difference in terms of gender (p=0.08). In response to therapy there was no difference between two groups (p=0.09%) after 6 months follow up relapse rate was 18% in cryotherapy patients and only 8%in 5-FU group which wasn't statistically meaningful and no difference was observed between two groups (p=0.27).

 Conclusion: The results indicated that course of treatment was shorter in cryotherapy than the topical 5- FU but the relapse rate didn't have any difference between two groups. The only significant difference was pain in which 5- FU was painless but cryotherapy was painful.