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:: Volume 23, Issue 2 (summer 2023) ::
J Ardabil Univ Med Sci 2023, 23(2): 111-125 Back to browse issues page
Premature Ovarian Insufficiency Treatment with Human Mesenchymal Stem Cells
Reza Javanshir , Ramin Salimnejad , Mohammad Ghasem Golmohammadi , Hossein Kalarestaghy *
Department of Anatomical Sciences, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran. , h.kalarestaghy111@gmail.com
Abstract:   (929 Views)
Premature Ovarian Insufficiency (POI) refers to the loss of ovarian function before the age of 40. This condition can be attributed to various factors including X chromosome abnormalities, autoimmune disorders, and chemotherapy drugs. Hormone therapy is a commonly used treatment for POI, but due to side effects and low fertility rates, alternative treatment options are needed. In recent years, stem cell transplantation has emerged as a promising treatment approach, offering hope for improving and restoring ovarian function. Stem cells possess the unique ability of self-renewal and regeneration, making them potentially effective in addressing ovarian failure and subsequent infertility. Different types of stem cells have been investigated for the treatment of POI, including mesenchymal stem cells (MSCs), stem cells from extraembryonic tissues, induced pluripotent stem cells (iPSCs), and ovarian stem cells. This article aims to provide an overview of the causes and treatment options for Premature Ovarian Insufficiency, with a particular focus on stem cell therapy as suggested by previous studies.
 Corresponding Author: Hossein Kalarestaghy,  Department of Anatomical Sciences, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
Email: h.kalarestaghy111@gmail.com
google scholar
pubmed


 
Article number: 1
Keywords: Mesenchymal Stem Cell, Premature Ovarian Insufficiency, Infertility
Full-Text [PDF 663 kb]   (416 Downloads)    
Type of Study: review article | Subject: Gynecology
Received: 2023/06/11 | Accepted: 2023/09/9 | Published: 2023/10/2
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Javanshir R, Salimnejad R, Golmohammadi M G, Kalarestaghy H. Premature Ovarian Insufficiency Treatment with Human Mesenchymal Stem Cells. J Ardabil Univ Med Sci 2023; 23 (2) : 1
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