[Home ] [Archive]   [ فارسی ]  
:: Main In Press Current Issue All Issues Search register ::
Main Menu
Home::
Journal Information::
Editorial Board::
Articles archive::
For Authors::
For Reviewers::
Editorial Policy::
Registration::
Contact us::
::
..
Indexing

 

 

 

 

 
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Creative commons

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

..
:: Volume 21, Issue 1 (spring 2021) ::
J Ardabil Univ Med Sci 2021, 21(1): 76-89 Back to browse issues page
The Relationship between Gastric Carcinogenesis Susceptibility and Some SNPs in MicroRNA Genes in General Population of Ardabil Province
Homa Akhavan Aghghaleh , Najmeh Ranji * , Hadi Habibollahi
Department of Biology, Faculty of Sciences, Rasht Branch, Islamic Azad University, Rasht, Iran. , n_ranji@iaurasht.ac.ir
Abstract:   (1205 Views)
Background & Objectives: Gastric cancer is the fourth most common cancer in the world and Ardabil province is in the top ranks in the world. MicroRNAs are non-coding RNA molecules with a length of 18 to 21 nucleotides and due to their regulatory role in post- transcriptional gene expression; single nucleotide polymorphisms (SNPs) could affect their function on target genes regulation.
Methods: Genomic DNA was extracted from peripheral blood of 150 healthy volunteers, which were born and living in Ardabil province, 30 SNPs in microRNA genes have been detected by the Whole Exome Sequencing assay. Then, the obtained results were evaluated using Sanger-based PCR-Sequencing method. The Pearson correlation test was used for finding significant relationships.
Results: After confirming the WES results, the population frequency of the selected variants was compared with the general populations of Iran, Europe and the world. Based on the age-standardized rate (ASR), six variants with significant differences, including rs10061133, rs12220909, rs12983273, rs2292832, rs2505901 and rs6505162 were observed.
Conclusion: According to the previous case-control studies which indicate the association between the variants rs10061133, rs12220909, rs12983273, rs2505901, and rs6505162 and gastric carcinogenesis in various populations, the observed significant differences in our population could imply on the presence of the cancer susceptibility in Ardabil province.
Keywords: Gastric Cancer, Ardabil, MicroRNA, SNPs, WES
Full-Text [PDF 842 kb]   (401 Downloads)    
Type of Study: article | Subject: Genetics and molecular medicine
Received: 2021/09/7 | Accepted: 2022/02/19 | Published: 2021/03/30
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA

Ethics code: IR.IAU.RASHT.REC.1398.057



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Akhavan Aghghaleh H, Ranji N, Habibollahi H. The Relationship between Gastric Carcinogenesis Susceptibility and Some SNPs in MicroRNA Genes in General Population of Ardabil Province. J Ardabil Univ Med Sci 2021; 21 (1) :76-89
URL: http://jarums.arums.ac.ir/article-1-2048-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 21, Issue 1 (spring 2021) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
Persian site map - English site map - Created in 0.15 seconds with 41 queries by YEKTAWEB 4623