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The Effects of Chicory Hydroalcoholic Extract Along with Treadmill Walking on Tissue and Serum Hepatic Transaminases Levels in Rats with Non-Alcoholic Fatty Liver Disease
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smat Sefidkerdar    , Seyed ebrahim Hosseini * |
| Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran , ebrahim.hossini@yahoo.com |
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Abstract: (5799 Views) |
Background & objectives: Non-alcoholic fatty liver is one of the most common diseases. Nutrition and exercise are recommended for the patients with this disease, and chicory is considered due to its protective effects on the liver. Therefore, the aim of the present study was to investigate the effect of chicory extract along with treadmill walking on the hepatic transaminases levels and tissue changes in rats with non-alcoholic fatty liver disease.
Methods: In this experimental study, 56 mature male rats were divided into control (without treatment), sham (treatment with high-fat diet 10 ml/kg) and 5 experimental groups receiving high-fat diet (10 ml/kg) with 200 and 100 mg/kg chicory extract alone and with treadmill walking. Chicory was administered as gavage in 28 consecutive days. At the end, after anesthetizing the animals and collecting blood from their hearts the Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT) and Alkaline phosphatase (ALP) enzymes were measured. The their livers were removed and after preparing the tissue sections, the results of hepatic enzymes measurements were analyzed by ANOVA and Duncan tests and P≤0.05 was considered significant.
Results: The results showed that high-fat diet increased AST, ALT and ALP enzymes and hepatic tissue damage compared to the control group at p<0.001. Treatment with chicory and treadmill walking alone and together resulted in a significant reduction of the above enzymes at p<0.001 and improvement of hepatic tissue compared to the high-fat diet group.
Conclusion: The results showed that high-fat diet increased the levels of ALT, AST and ALP, and hepatic tissue damage. Treadmill walking and chicory extract alone and together reduced the above enzymes and improved the hepatic tissue structure. |
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| Keywords: Non-Alcoholic Fatty Liver, AST, ALP, ALT, Treadmill, Chicory |
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Full-Text [PDF 567 kb]
(2078 Downloads)
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Type of Study: article |
Subject:
General
Received: 2017/10/23 | Accepted: 2018/04/19 | Published: 2018/07/1
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