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:: Volume 18, Issue 1 (spring 2018) ::
J Ardabil Univ Med Sci 2018, 18(1): 7-20 Back to browse issues page
A Cellular Perspective on the Importance of Oxidative Stress Effects on Sperm
Niloofar Sadeghi , Marzieh Tavalaee , Mohammad Hosein Nasr- Esfahani
Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
Abstract:   (714 Views)
 
Infertility, especially in the last decade, has been rising as a global problem, affecting approximately 10-15% of the world's population. The abundance and origin of various types of infertility are different. Studies have shown that reactive oxygen species (ROS) are involved in infertility, in particular in male infertility. Although ROS is essential for normal physiological functions of sperm such as capacitation, hyper activation, acrosome reactions, and binding to the oocyte, excessive levels can be one of the main causes of defective sperm function, which not only impairs the health of sperm DNA, but also affects fertilization via oxidation of proteins, in particular the fatty acids of the sperm cell membrane. Also, the elevated ROS levels facilitate sperm DNA damage, which leads to activation of apoptotic pathway and cell death. Therefore, the quality of semen is functionally reduced. Since the oxidative damage to sperm DNA is associated with both miscarriage and development abnormalities in the offspring, it is essential to find new strategies to recognize the cellular and molecular biology of sperm. Therefore, considering different mechanisms of oxidative stress affecting sperm can contribute significantly to the etiology of male infertility
Keywords: ROS, RNS, DNA Damage, Infertility, Antioxidant
Full-Text [PDF 301 kb]   (197 Downloads)    
Type of Study: review article | Subject: General
Received: 2017/10/23 | Accepted: 2018/02/19 | Published: 2018/03/29
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Sadeghi N, Tavalaee M, Nasr- Esfahani M H. A Cellular Perspective on the Importance of Oxidative Stress Effects on Sperm . J Ardabil Univ Med Sci. 2018; 18 (1) :7-20
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Volume 18, Issue 1 (spring 2018) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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