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:: مقالات آماده انتشار ::
برگشت به فهرست مقالات برگشت به فهرست نسخه ها
مروری بر روند توسعه واکسن‌های لیشمانیوز
نرگس خاقان زاده ، فاطمه جوادی ، افشین سمیعی*
مرکز تحقیقات غدد و متابولیسم، دانشگاه علوم پزشکی هرمزگان، بندرعباس، ایران ، afshin.samiei@hums.ac.ir
چکیده:   (71 مشاهده)
لیشمانیوز یک بیماری عفونی انگلی است که سالانه حدود یک میلیون مورد جدید آن رخ می‌دهد. درمان این بیماری چالش‌برانگیز بوده و هزینه‌های بالایی به‌ویژه در کشورهای در حال ‌توسعه ایجاد می‌کند. مطالعات زیادی بر روی اشکال متنوع واکسن‌ها ازجمله انگل‌های زنده تخفیف حدت یافته، کشته‌شده، آنتی‌ژن‌های زیر واحدی، واکسن‌های نوترکیب و یا تکنولوژی DNA انجام شده است. بااین‌وجود، هنوز واکسن پیشگیری‌کننده مؤثر و کاربردی در سطح گسترده برای لیشمانیوز وجود ندارد. هدف از مطالعه حاضر بررسی روند توسعه واکسن‌های لیشمانیوز است.
مقالات این مطالعه از پایگاه‌های PubMed ،  Web of Scienceو Scopus با جستجوی کلیدواژه‌های مرتبط و بر اساس موضوع، کیفیت علمی و تاریخ انتشار با تمرکز بر مقالات جدیدتر انتخاب شدند.
مطالعات انجام‌شده در زمینه توسعه واکسن‌های لیشمانیوز نشان می‌دهد برخی از واکسن‌ها همچون Leishmune، CaniLeish و Leish-Tec که در مراحل مختلف آزمایش‌های بالینی قرار دارند، می‌توانند به‌ عنوان گزینه‌های مناسب برای کنترل و پیشگیری از لیشمانیوز در سگ مورد استفاده قرار گیرند. واکسن LeishChim که با تکنیک­های ایمونوانفورماتیک و داکینگ مولکولی طراحی شده نتایج اثربخشی را در مطالعات موشی نشــان داده است. همچنین واکسن زنده مبتنی بر جهش ژن سنترین LmCen-/- ، فاز I کارآزمایی بالینی در انسان را سپری کرده است.
با توجه به اهمیت توسعه واکسن لیشمانیوز، تحقیقات در این زمینه همچنان ادامه دارد. استفاده از مطالعات ایمونوانفورماتیکی و مدل‌سازی زیستی می‌تواند به شناسایی سریع‌تر کاندیداهای واکسن مؤثر کمک کند.
واژه‌های کلیدی: لیشمانیوز، واکسن، لیشمانیوز جلدی، لیشمانیوز جلدی- مخاطی، لیشمانیوز احشایی
متن کامل [PDF 529 kb]   (71 دریافت)    
نوع مطالعه: مقاله مروری | موضوع مقاله: ایمنولوژی
دریافت: 1403/3/29 | پذیرش: 1403/5/31
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