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:: Volume 17, Issue 4 (winter 2018) ::
J Ardabil Univ Med Sci 2018, 17(4): 392-401 Back to browse issues page
Protective Effect of L-Carnitine on the Sperm Parameters of Adult Mice Treated with Ciprofloxacin
Mina Kiani , Paria Parto
Department of Biology ,School of sciences, Razi University,Kermanshah, Iran
Abstract:   (947 Views)
Background & objectives: The present study examined the gonadotoxic effects of ciprofloxacin antibiotics and protective effects of L-carnitine.
Methods: In this study, 20 NMRI mice were divided into four groups: control, ciprofloxacin, L-carnitine, L-carnitine-ciprofloxacin (each group included 5 animals). The control group received normal saline, the treatment group 1 received 12.5 mg/kg ciprofloxacin, the treatment group 2 received 100 mg/kg L- carnitine and the treatment group 3 received 100 mg/kg L- carnitine and 12.5 mg / kg ciprofloxacin simultaneously. All animals were treated by intraperitoneal administration for 15 days. Testis and epididymis were collected to evaluate sperm parameters (sperm count, motility, morphology and viability).
Results: In the ciprofloxacin group, a significant decrease in sperm count, sperm viability, sperm motility, progressive sperm motility and normal sperm as well as a significant increase in rotating sperm motility, sperm without movement, head and tail abnormalities were observed (p≤0.05). A significant increase in sperm count, sperm survival, motility and progressive sperm motility, normal sperm and a significant decrease in rotating sperm motility, sperm without movement and head abnormalities in the L-carnitine-ciprofloxacin group were observed (p≤0.05); however, the reduction in tail abnormalities of sperm was not significant.
Conclusion: L-carnitine improves sperm parameters in the adult mice treated with ciprofloxacin.
Keywords: L- Carnitine, Ciprofloxacin, Sperm Parameters, Mice
Full-Text [PDF 1222 kb]   (289 Downloads)    
Type of Study: article | Subject: General
Received: 2017/04/19 | Accepted: 2017/08/21 | Published: 2017/12/31
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Kiani M, Parto P. Protective Effect of L-Carnitine on the Sperm Parameters of Adult Mice Treated with Ciprofloxacin . J Ardabil Univ Med Sci. 2018; 17 (4) :392-401
URL: http://jarums.arums.ac.ir/article-1-1483-en.html


Volume 17, Issue 4 (winter 2018) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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