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The effect of 8-weeks of High-intensity Interval Training and Hawthorn Extract on PGC-1α and TFAM Proteins Levels in the Soleus Muscle of Aged Rats
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Fatemeh Saedi    , Mahmoud Nikseresht * , Abdolhossein Taheri Kalani |
| Department of Sport Sciences, Faculty of Humanities, Ilam Branch, Islamic Azad University, Ilam, Iran , nikserasht@gmail.com |
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Abstract: (767 Views) |
Background & objectives: Maintaining the capacity of mitochondrial biogenesis during aging is considered a key factor to prevent the development of age-related diseases. this study aimed to investigate the effect of 8-weeks of high-intensity interval training (HIIT) and hawthorn extract on the peroxisome proliferator- activated receptor-γ gamma coactivator-1α (PGC-1α) and mitochondrial transcription factor A (TFAM) proteins levels in the soleus muscle of aged rats.
Methods: Thirty-six aged rats were randomly and equally assigned into control (CON), HIIT, extract or combined (COM, HIIT+ extract) groups. The HIIT protocol consisted of 6 to 9 sets×5-min of running on a treadmill, which was performed 4 minutes at 16 m/min and one minuteat a speed velocity of 25 m/min, 5 times a week for 8 weeks. Over the intervention period, rats in the extract and COM groups received 100 mg/kg per day hawthorn. After the interventions, TFAM and PGC-1α protein expression levels were detected in the soleus muscle using the western blotting method.
Results: There was a significant increase in PGC-1α for all interventions when compared to the CON, although this increase in the COM was significantly higher than the other groups. After 8 weeks , there was a significant increase in TFAM level in extract group compared to CON,also, the training groups had more effects on this marker in comparison to the former intervention (p>0.05).
Conclusion: It seems that, 8-weeks of the HIIT+ intake hawthorn is a more efficient approach in improving mitochondrial oxidative capacity compared to HIIT and extract alone.
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Article number: 2 |
| Keywords: Hawthorn, High Intensity Interval Training, Mitochondrial Biogenesis, Rat, Aging |
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Full-Text [PDF 468 kb]
(242 Downloads)
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Type of Study: article |
Subject:
تربیت بدنی- فیزیولوژی ورزش
Received: 2023/02/6 | Accepted: 2023/04/18 | Published: 2023/05/10
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