[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 20, Issue 3 (autumn 2020) ::
J Ardabil Univ Med Sci 2020, 20(3): 397-409 Back to browse issues page
The Effect of Combined and Rehabilitation Training on ABCA1 Gene Expression in Blood Lymphocytes and Lipid Profile in Middle-aged Men with Coronary Bypass Graft
Ali Akbar Moradi , Amir Rashid Lamir , Rambod Khajeie , Ahmad Zendedel , Akbar Safipour Afshar
Department of Physical Education, Neyshabour Branch, Islamic Azad University, Neyshabour, Iran
Abstract:   (276 Views)
Background & objectives: ABCA1 plays an important role in HDL biosynthesis and cellular cholesterol homeostasis and is effective in preventing the formation of atherosclerotic plaques. This study aimed to investigate the effect of combined and rehabilitation training on ABCA1 gene expression in blood lymphocytes and lipid profile in middle-aged men with coronary bypass graft.
Methods: In this quasi-experimental study, 45 middle-aged men (mean age: 55.58±4.7 years) were selected by convenience sampling method and randomly divided into three groups of combined training (15 people), rehabilitation (n=15), and control (n=15). The combined training group included resistance and aerobic exercises and rehabilitation training group included aerobic exercises for 8 weeks (3 sessions per week). Blood samples were taken from all subjects at weeks 0 and 8 to measure the expression levels of ABCA1, HDL, and LDL genes. Kruskal-Wallis, one-way ANOVA, and Tukey post hoc tests were used for statistical analysis using SPSS software, and significance level was p≤0.05 .
Results: The results showed that eight weeks of combined training and rehabilitation training increased the expression level of the ABCA1 (p=0.001 and p=0.001, respectively) gene and plasma HDL (p=0.001 and p=0.012, respectively) level and decreased plasma LDL (p=0.001 and p=0.01, respectively) level. There was also a significant difference between the three groups in ABCA1 and HDL values in favor of the combined training group. 
Conclusion: It seems that combined training can be more effective than rehabilitation training to further increase ABCA1 gene expression and plasma HDL levels and decrease LDL level in middle-aged men with coronary bypass graft.
Keywords: ABCA1, Combined Training, Rehabilitation, Middle-aged Men, Coronary Bypass Graft
Full-Text [PDF 264 kb]   (100 Downloads)    
Type of Study: article | Subject: قلب و عروق
Received: 2020/12/29 | Accepted: 2021/05/20 | Published: 2021/07/11
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Moradi A A, Rashid Lamir A, Khajeie R, Zendedel A, Safipour Afshar A. The Effect of Combined and Rehabilitation Training on ABCA1 Gene Expression in Blood Lymphocytes and Lipid Profile in Middle-aged Men with Coronary Bypass Graft. J Ardabil Univ Med Sci. 2020; 20 (3) :397-409
URL: http://jarums.arums.ac.ir/article-1-1969-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 20, Issue 3 (autumn 2020) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
Persian site map - English site map - Created in 0.08 seconds with 30 queries by YEKTAWEB 4331