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:: Volume 20, Issue 1 (spring 2020) ::
J Ardabil Univ Med Sci 2020, 20(1): 104-115 Back to browse issues page
Comparison of the Sedative Effect of Ketofol and The Combination of Midazolam-Ketamine in Upper GI Tract Endoscopy in 1-14 Years Childeren
Vahid َAdiban , Somaieh Matin , Mohammad Hassanpour- Darghah , Mir Salim Seyed Sadeghi , Kobra Ghorbanzadeh
Department of Internal Medicine, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
Abstract:   (92 Views)
Background & objectives: Endoscopy is an invasive and painful procedure. The use of sedatives, especially in children, is expanding. The aim of this study was to compare the sedative effects of ketofol and the combination of midazolam-ketamine in upper endoscopy in children aged 1 to 14 years who referred to Taleghani Hospital in Gorgan.
Methods: In this study, 55 children entered the study 1 to 14 years after obtaining parental consent. They were then divided into two groups, ketamine-propofol (KP) and ketamine-midazolam (KM), by simple randomization. At all stages of the work, patients underwent cardiac and respiratory monitoring. All hemodynamic parameters and ramsy sedation score (RSS) were recorded for all participants in the 5 time periods before, during and after endoscopy. ANOVA test and bonferroni tracking test were used in spss software to analyze and compare data.
Results: 54.5% were male patients. The ANOVA test showed that the scores of the two groups at the time of the study had a statistically significant difference (p=0.02). In the KM group, the mean blood pressure and heart rate of patients increased at all times compared to before the intervention (p=0.005). Blood pressure in the KP group had a steady trend over time (p<0.001).
Conclusion: There was a statistically significant difference between the scores of the two groups and the group (KM) had higher scores, but the use of two drug regimens Propofol-Ketamine and Ketamine-Midazolam caused a good sedation in pediatric endoscopy. The propofol-ketamine compound resulted in greater hemodynamic stability in cardiovascular parameters during and after endoscopy
Keywords: Ketofol, Endoscopy, Pediatrics, Midazolam, Ketamine
Full-Text [PDF 182 kb]   (36 Downloads)    
Type of Study: article | Subject: گوارش و کبد
Received: 2020/05/29 | Accepted: 2020/08/20 | Published: 2020/09/22
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َAdiban V, Matin S, Hassanpour- Darghah M, Seyed Sadeghi M S, Ghorbanzadeh K. Comparison of the Sedative Effect of Ketofol and The Combination of Midazolam-Ketamine in Upper GI Tract Endoscopy in 1-14 Years Childeren. J Ardabil Univ Med Sci. 2020; 20 (1) :104-115
URL: http://jarums.arums.ac.ir/article-1-1868-en.html


Volume 20, Issue 1 (spring 2020) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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