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:: Volume 20, Issue 1 (spring 2020) ::
J Ardabil Univ Med Sci 2020, 20(1): 59-78 Back to browse issues page
Investigating the Effect of Endurance Training and Supplementation of Persia Rosa Extract on Mitochondrial Apoptosis of Myocardium
Aylar Imani , Marefat Siahkouhian , Pouran Karimi , Masoud Asgharpour-Arshad , Farnaz Seifi-Ski-shahr
Department of Physical Education and Sport Sciences, Faculty of Education and Psychology, Mohaghegh Ardabili University, Ardabil, Iran
Abstract:   (111 Views)
 
Background & objectives: Physical training and some supplements through different mechanisms could be effective in reducing apoptosis; the aim of this study was to investigate the effect of endurance training and supplementation of Persia Rosa extract on mitochondrial apoptosis of myocardium.
Methods: In this experimental study, 52 male rats were randomly assigned into five homogeneous groups, three-month control, six months control, Persia Rosa supplement, endurance training and endurance training+Persia Rosa. Training groups participated in endurance training protocol for 12 weeks. The Persia Rosa and endurance training+Persia Rosa groups received 1 gram Persia Rosa extract per kg body weight. After the implementation of the training protocol and consumption of the extract, the surgical and cardiac tissue extraction procedures were performed. The data were analyzed by ANOVA test and Bonferroni post hoc tests at the significant level of less than 5% using SPSS-22 software.
Results: The results showed that Bax/Bcl-2 ratio and Caspase-3 gene expression were significantly decreased in endurance training and endurance training+Persia Rosa groups to the control group (p˂0.05). Bax/Bcl-2 showed a significant decrease in the Persia Rosa supplement group (p˂0.05), but Caspase-3 was not significant in the Persia Rosa supplement group.
Conclusion: It is expected that the effect of endurance training with consumption of Persia Rosa extract on Bax/Bcl-2 ratio and Caspase-3 will provide a good platform for caspase mechanisms and apoptosis processes in the myocardium of rats.
Keywords: Myocardium, Bax to Bcl-2 Ratio, Caspase-3, Persia Rosa, Endurance Training
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Type of Study: article | Subject: تربیت بدنی- فیزیولوژی ورزش
Received: 2020/04/24 | Accepted: 2020/08/20 | Published: 2020/09/22
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Imani A, Siahkouhian M, Karimi P, Asgharpour-Arshad M, Seifi-Ski-shahr F. Investigating the Effect of Endurance Training and Supplementation of Persia Rosa Extract on Mitochondrial Apoptosis of Myocardium. J Ardabil Univ Med Sci. 2020; 20 (1) :59-78
URL: http://jarums.arums.ac.ir/article-1-1846-en.html


Volume 20, Issue 1 (spring 2020) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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