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:: Volume 19, Issue 4 (winter 2020) ::
J Ardabil Univ Med Sci 2020, 19(4): 400-409 Back to browse issues page
The Effect of Rosa canina Extract Against Paraquat-induced Lung Injury
Keyvan Amirshahrokhi
Department of Pharmacology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran
Abstract:   (157 Views)
 
Background & objectives: Paraquat is a toxic herbicide that is widely used in many countries. Paraquat selectively accumulates in the lung tissue and leads to severe pulmonary injury through the oxidative and inflammatory processes. The plant Rosa canina L. has been used for long years as an herbal medicine throughout the world. Rosa canina L. is a member of Rosacea family and shows therapeutic effects against numerous disorders by its antioxidant and anti-inflammatory properties. The aim of this study was to evaluate the antioxidant effect of Rosa canina fruits on the paraquat induced lung injury in a mouse model.
Methods: Animal experiments were performed on male NMRI mice. Paraquat was injected at a single dose (20 mg/kg, ip) to induce pulmonary damage in mice. The extract of Rosa canina fruits (200 and 400 mg/kg/day, orally) administered by gavage for four days after the injection of paraquat. The treated mice were compared to normal mice as a control group. At the end of the experiment, lung tissue samples were collected for biochemical analysis.
Results: The results showed that administration of paraquat caused an oxidant-antioxidant imbalance in the lung tissue. However, treatment with Rosa canina increased the levels of glutathione (GSH) and catalase (CAT) antioxidants and decreased the levels of malondialdehyde (MDA) and myeloperoxidase (MPO) in the lung tissues compared with those in the paraquat group.
Conclusion: Treatment of paraquat-exposed mice with the extract of Rosa canina fruits improved oxidant-antioxidant balance in the lung tissue of mice. In other words, the present study demonstrated that Rosa canina has remarkable antioxidant effects against paraquat induced oxidative damage.
 
Keywords: Rosa canina L., Paraquat, Lung Injury, Antioxidant Effects
Full-Text [PDF 187 kb]   (37 Downloads)    
Type of Study: article | Subject: فارماکولوژی
Received: 2019/10/22 | Accepted: 2019/12/21 | Published: 2020/06/30
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Amirshahrokhi K. The Effect of Rosa canina Extract Against Paraquat-induced Lung Injury. J Ardabil Univ Med Sci. 2020; 19 (4) :400-409
URL: http://jarums.arums.ac.ir/article-1-1796-en.html


Volume 19, Issue 4 (winter 2020) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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