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The Effect of Swimming Training plan and Vitamin B6 Intake on GATA2 Gene Expression in Endometriosis Rat Model
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Sepideh Ghasemian    , Parvin Farzanegi * , Lida Moradi |
| Department of Sport Physiology, Sari Branch, Islamic Azad University, Sari, Iran , parvin.farzanegi@gmail.com |
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Abstract: (3009 Views) |
Background & objectives: In the pathogenesis of endometriosis, a variety of genes are involved. The aim of this study was to investigate the GATA2 gene expression changes in endometriosis rat model following a period of aerobic exercise and vitamin B6 intake.
Methods: For this purpose, 25 adult Wistar rats were randomly divided into 5 groups, including: healthy control, patient control, patient+training, patient+vitamin, patient+vitamin+ training. In order to create an endometriosis model, rats were first anesthetized and after opening abdominal muscle, ovarian tissue and part of uterine tissue were removed and were inserted into a sterile container with one cc of PBS and sliced. Tissue fragments were transplanted into the abdominal and ovarian areas. The amount of vitamin intake was 60mg/kg and swimming program lasted 8 weeks, 30 minutes a day, five days a week. One-way ANOVA test and Tukey post hoc test were used for data analysis.
Result: The results showed that a period of swimming exercise program in the patient + training group significantly increased the GATA2 level compared to the patient control group (p≤0.001). Also, the GATA2 gene expression level was significantly increased in the patient + training + vitamin group compared to the patient control group (p=0.002). However, its level in the patient group was significantly lower than that of the healthy control group (p≤0.001).
Conclusion: Regular aerobic exercise combined with intake of vitamin B6 may decrease GATA2 gene expression level in endometrial rat model.
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| Keywords: Swimming, Vitamin, GATA2, Endometriosis |
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Full-Text [PDF 303 kb]
(1973 Downloads)
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Type of Study: article |
Subject:
Exercise physiology
Received: 2019/10/22 | Accepted: 2019/12/21 | Published: 2019/10/2
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