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:: Volume 19, Issue 4 (winter 2020) ::
J Ardabil Univ Med Sci 2020, 19(4): 410-417 Back to browse issues page
The Relationship between IL-1β-511 Polymorphism and Gastric Cancer in Ardabil Province, Iran
Effat Seyedhashemi , Elham Niasti , Nima Farahmand , Mohammad Mazani , Abbas Yazdanbod , Firouz Amani , Seyyed Saeid Hossini-Asl
Genetic laboratory, Imam Hospital, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
Abstract:   (170 Views)
 
Background & objectives: Gastric cancer has a very wide geographic distribution. Identification of the genetic factors involved in the cancer predisposition is very important. IL-1β as a pro inflammatory cytokine is involved in gastric acid secretion in the H. pylori infected individuals. This study was aimed to evaluate the role of IL-1β-511 polymorphism on the susceptibility to gastric cancer in residents of Ardabil province.
Methods: One-hundred patients affected with gastric cancer and 100 normal individuals were selected as case and control groups, respectively. After DNA extraction from peripheral blood samples, the presence of the polymorphism IL-1β-511 was determined via PCR-RFLP assay. The results were evaluated by agarose gel electrophoresis.
Results: Among cases, CC, CT, and TT genotypes were observed in 19%, 60%, and 21% of individuals, respectively. Also, the distribution of genotypes among the participated individuals in control group was 4%, 67%, and 29%, respectively. There was a significant difference (p<0.05) between case and control groups.
Conclusion: According to this study, there was a significant relationship between IL-1β 511C allele polymorphism and gastric cancer in patients with gastric cancer in Ardabil province. It is indicated that some of the polymorphisms in IL-1β cytokine are associated with gastric cancer, and this finding would be used as a predictive value.
Keywords: Gastric Cancer, Polymorphism, IL-1β-511
Full-Text [PDF 170 kb]   (44 Downloads)    
Type of Study: article | Subject: گوارش و کبد
Received: 2019/10/22 | Accepted: 2019/12/21 | Published: 2020/06/30
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Seyedhashemi E, Niasti E, Farahmand N, Mazani M, Yazdanbod A, Amani F et al . The Relationship between IL-1β-511 Polymorphism and Gastric Cancer in Ardabil Province, Iran. J Ardabil Univ Med Sci. 2020; 19 (4) :410-417
URL: http://jarums.arums.ac.ir/article-1-1771-en.html


Volume 19, Issue 4 (winter 2020) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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