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:: Volume 19, Issue 2 (summer 2019) ::
J Ardabil Univ Med Sci 2019, 19(2): 161-171 Back to browse issues page
Anti-inflammatory and Anti-nociceptive Activities of Hydroalcoholic Extract of Rosa canina L. Fruit in Male Mice
Rahmatollah Parandin , Leili Mohammadi
Department of Biology, Faculty of Sciences, Payame Noor University, Tehran, Iran
Abstract:   (249 Views)
 
Background & objectives: In recent years, regarding the side effects of chemical drugs, the use of medicinal plants has increased due to their low side effects, low costs and effective compounds. The aim of this study was to investigate the anti-inflammatory, anti-nociceptive, and anti-pyretic effects of hydroalcoholic extract of Rosa canina L. fruit in male mice.
Methods: In this experimental study, 120 male BALB/c mice weighing 23-30 g were used. In each test, the mice were divided into 5 groups (in each group, n=6), including control group, positive control and three experimental groups treated intraperitoneally with hydroalcoholic extract of Rosa canina L. fruit at doses of 100, 200 and 400 mg/kg respectively. The anti-inflammatory and antipyretic activities were measured using xylene-induced ear edema and brewer’s yeast-induced pyrexia tests, respectively. In addition, the antinociceptive activity was measured using the abdominal constrictions induced by acetic acid and formalin tests. The data were analyzed by SPSS statistical software and One Way ANOVA test. The level of significance was set at   p<0.05.
Results: 200 (p<0.05) and 400 mg/kg (p<0.001) doses of extract reduced significantly inflammation. Doses of 100 (p<0.05), 200 (p<0.01) and 400 (p<0.001 significantly reduced pain in the abdominal constriction test and dose of 400 mg/kg (p<0.05) decreased the chronic pain in formalin test. Extract treatment did not reduce fever in any of the existing doses.
Conclusions: The findings of this study suggest that Rosa canina L. fruit has anti-inflammatory and visceral analgesic activity, which may be due to its antioxidant potential.
 
Keywords: Rosa canina L., Pain, Inflammation, Mice, Fever
Full-Text [PDF 208 kb]   (49 Downloads)    
Type of Study: article | Subject: فیزیولوژی
Received: 2019/02/19 | Accepted: 2019/06/20 | Published: 2019/09/21
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Parandin R, Mohammadi L. Anti-inflammatory and Anti-nociceptive Activities of Hydroalcoholic Extract of Rosa canina L. Fruit in Male Mice . J Ardabil Univ Med Sci. 2019; 19 (2) :161-171
URL: http://jarums.arums.ac.ir/article-1-1722-en.html


Volume 19, Issue 2 (summer 2019) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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