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:: Volume 16, Issue 1 (spring 2016) ::
J Ardabil Univ Med Sci 2016, 16(1): 7-15 Back to browse issues page
The Effect of Pre-Nutrition of Hydroalcoholic Extracts of Origanum vulgare on Infarct Volume and Neurologic Deficits in a Rat Stroke Model
Meysam Foroozandeh, Mohammadreza Bigdeli, Mehdi Rahnema
Department of Physiology, School of Biological Sciences, Shahid Beheshti University, Tehran, Iran
Abstract:   (5886 Views)

Background & objectives: Basic and clinical studies have shown that the production of free radicals was one of the main factors leading to the injury after stroke. In this study we investigated the effect of hydroalcoholic extracts of Origanum vulgare on infarct volume and neurological deficits in a rat stroke model.

Methods: In this experimental study 35 male Wistar rats were randomly divided into 5 groups, each containing 7 animals. First group (control) received distilled water, while other three treatment groups received oral Origanum vulgare extract by gavage for 30 days (50, 75 and 100 mg/kg/day, respectively). These groups were subjected to 60 min middle cerebral artery occlusion 2 hours after the last dose of Origanum extracts and followed by 24 hrs reperfusion. After 24 hrs, the infarct volume and neurologic deficits were evaluated in the groups. Sham operated groups (n=7) did not receive Marjoram and brain ischemia.

Results: The hydroalcoholic extract of Origanum reduced the infarct volume and neurologic deficits in all treatment groups compared to control group.

Conclusion: It seems that Origanum vulgare extract can exert the neuroprotective effect against stroke damage by reducing infarct volume and neurological disorders.

Keywords: Origanum vulgare, Infarct Volume, Neurological Deficits, Stroke
Full-Text [PDF 164 kb]   (1897 Downloads)    
Type of Study: article | Subject: General
Received: 2015/06/1 | Accepted: 2015/10/29 | Published: 2016/04/14
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Foroozandeh M, Bigdeli M, Rahnema M. The Effect of Pre-Nutrition of Hydroalcoholic Extracts of Origanum vulgare on Infarct Volume and Neurologic Deficits in a Rat Stroke Model. J Ardabil Univ Med Sci. 2016; 16 (1) :7-15
URL: http://jarums.arums.ac.ir/article-1-1038-en.html


Volume 16, Issue 1 (spring 2016) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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