:: Volume 21, Issue 2 (summer 2021) ::
J Ardabil Univ Med Sci 2021, 21(2): 139-149 Back to browse issues page
Evaluation of Antioxidant and cytotoxic Effects of Cinnamon-Coated Cerium Oxide Nanoparticles on PC12 Cell Line
Abbas Sabahi Namini , Arash Abdolmaleki * , Sharareh Mirzaee , Mehrdad Sheikhlou , Asadollah Asadi , Ali Shamsazar
Department of Bioinformatics, Faculty of Advanced Technologies, University of Mohaghegh Ardabili, Namin, Iran
Abstract:   (362 Views)
Background & objectives: Research on intelligent nanomaterials that accelerate the process of nerve regeneration and treatment by different methods such as antioxidant effects, stimulation of nerve cell proliferation, modulation of the immune system and inflammatory factors is great importance. The aim of this study was to prepare cinnamon-coated cerium oxide nanoparticles and evaluate its antioxidant and cytotoxicity effects on PC12 cell line.
Methods: Cinnamon-coated cerium oxide nanoparticles were prepared and their structural properties were evaluated by transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FTIR). To evaluate the antioxidant properties of the compounds, free radical trapping methods 2 and 2 diphenyl-1-picryl hydrazyl were used. Cell viability in the presence of compounds was measured by a toxicity test (MTT) [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide]. Data were analyzed by one-way analysis of variance and Tukey's post hoc test.
Results: FTIR spectra and TEM images showed the processing of nanoparticles with an average size of less than 100 nm with cinnamon coating on their surface. Also, the antioxidant capacity of cinnamon-coated cerium oxide nanoparticles was significantly higher (*p<0.038) than extracts and nanoparticles alone at similar concentrations. Evaluation the results of cytotoxicity showed that the lowest toxicity was observed in the cinnamon-coated cerium oxide nanoparticles group.
Conclusion: Results showed higher antioxidant properties and low cytotoxic effects of cinnamon-coated cerium oxide nanoparticles compared to other groups, which leads to better efficacy, proliferation, longer cell survival, its green synthesis and coverage by cinnamon
Keywords: Cerium Oxide Nanoparticles, PC12 Cell, Cell Toxicity, Antioxidant Effects
Full-Text [PDF 1988 kb]   (178 Downloads)    
Type of Study: article | Subject: فیزیولوژی
Received: 2022/03/1 | Accepted: 2022/06/9 | Published: 2021/07/1

Ethics code: IR.UMA.REC.1400.023



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Volume 21, Issue 2 (summer 2021) Back to browse issues page