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:: Volume 21, Issue 1 (spring 2021) ::
J Ardabil Univ Med Sci 2021, 21(1): 110-112 Back to browse issues page
The Effect of Moderate and High Intensity Resistance Training on the Expression of PGC-1α, TFAM and AMPK of Cardiomyocytes in Elderly Rats
Rohollah Taheri Gandomani , Bahman Mirzaei * , Arssalan Damirchi
2. Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Guilan, Rasht, Iran
Abstract:   (314 Views)
Background & objectives: Age-related cardiovascular dysfunction is often accompanied by impaired mitochondrial biogenesis and function. Exercise training can improve mitochondrial function and content in muscle to meet the energy demands of the cells. The purpose of the present study was to investigate the effect of moderate-intensity (MRT) and high-intensity (HRT) resistance training on the expression of PGC-1α, TFAM and AMPK of cardiomyocytes in elderly rats.
Methods: In this experimental study, 30 elderly male rats (23 months) were divided into 3 groups: control (C), MRT and HRT. Training groups exercised resistance training for eight weeks (5 days a week). The resistance training protocol consisted of climbing a 110- centimeter -long ladder, with a weight attached to a tail sleeve. In the MRT group, the training protocol with 60% MVCC, 14-20 times climbing the ladder; In the HRT group with 80% MVCC, 9-10 times climbing the ladder was performed. Data were tested using ANOVA at a significance level of p<0.05.
Results: the expression of PGC-1α, TFAM and AMPK was significantly increased in MRT and HRT groups compared to control group (p=0.000). There was no significant difference between MRT and HRT groups on the expression of PGC-1α, TFAM and AMPK (p=0.574).
Conclusions: Eight weeks of MRT and HRT exercise improved mitochondrial biogenesis by increasing the expression of AMPK, PGC-1α and TFAM Cardiomyocytes in Elderly Rats. Both types of exercise training may be considered an effective intervention to improve mitochondrial function
Keywords: Exercise, Organelle Biogenesis, Cardiac and Aging
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Type of Study: article | Subject: تربیت بدنی- فیزیولوژی ورزش
Received: 2021/11/30 | Accepted: 2022/04/12 | Published: 2021/03/30
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Ethics code: IR.IAU.M.REC.1400.012



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Taheri Gandomani R, Mirzaei B, Damirchi A. The Effect of Moderate and High Intensity Resistance Training on the Expression of PGC-1α, TFAM and AMPK of Cardiomyocytes in Elderly Rats. J Ardabil Univ Med Sci. 2021; 21 (1) :110-112
URL: http://jarums.arums.ac.ir/article-1-2072-en.html


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Volume 21, Issue 1 (spring 2021) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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