:: Volume 11, Issue 3 (autumn 2011) ::
J Ardabil Univ Med Sci 2011, 11(3): 228-237 Back to browse issues page
Oxidative Stress and Trace Elements in Patients with Non-Diabetic Hemodialysis
Reza Alipanahmogadam , Mohammad Mazani * , Abbas Naghizadeh Baghi , Ali Nemati , Mojtaba Amani , Bahman Bashardoost , Amir Mansour Vatankhah , Shahab Bohlooli
Abstract:   (18166 Views)

  Background & Objectives: Several evidences show that oxidative stress is high among patients with hemodialysis . This study was aimed to investigate the oxidative stress and serum level of zinc and copper in patients with non-diabetic hemodialysis .

  Methods: In a case-control study, 60 patients with non-diabetic hemdialysis referred to hemodialysis section, Ardabil Bou-Ali hospital, and 60 healthy individuals, matched by age and sex, were selected. In each group, lipid profile, blood glucose, creatinine, urea, total protein, albumin, zinc, copper, malondialdehyde, total antioxidant capacity, activity of glutathione peroxidase and superoxide dismutase were measured. The results were analyzed statistically by using Pearson correlation coefficient and Student-t test.

  Results: The amount of zinc, blood sugar, cholesterol, triglyceride, total protein, albumin, high density lipoprotein-C and low density lipoprotein-C were significantly lower in patients with hemodialysis in comparison with those in normal individuals. T he activity of superoxide dismutase, glutathione peroxidase in red blood cells and serum total antioxidant capacity were significantly high in patients in comparison with those in control group. However, serum concentrations of copper and malondialdehyde in two groups were not statistically different.

  Conclusion : The results of this study show that increase of antioxidant enzymes activity reduces the oxidative stress status in patients with non-diabetic hemodialysis . Zinc deficiency was also observed in these patients.

Keywords: Hemodialysis; Superoxide Dismutase; Glutathione Peroxidase; Oxidative Stress; Zinc
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Type of Study: article | Subject: Special
Received: 2011/04/7 | Accepted: 2011/08/11 | Published: 2011/09/23

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Volume 11, Issue 3 (autumn 2011) Back to browse issues page