Effect of Oral Administration of Ethanolic Extracts of Propolis on Passive Avoidance Learning and Memory in Adult Male Mice
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Nematollah Gheibi , Javad Shahbazi , Zahra Zarmohammadi , Mahmoud Alipoor Heydari , Eftekhar Kakaeie , Mohammad Sofiabadi * |
, mohasofi@yahoo.com |
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Abstract: (7336 Views) |
Background & objectives: Propolis is a natural product with powerful antioxidant and therapeutic effects. The aim of this study was to investigate the effect of propolis on passive avoidance memory in adult male mice.
Methods: In this study, 40 adult male mice were divided into 8 groups, including control, sham (solvent) and 3 treatment groups orally treated with 50, 100 and 200 mg/kg of propolis, respectively for two weeks before and one week after treatment. Then, passive avoidance learning and memory were recorded in timescales of 24 and 48 hours, 4 days and a week after shock by the shuttle box. Data were analyzed by ANOVA and Dunnett’s post hoc tests, and p<0.05 was considered significant.
Results: Administration of propolis (50 mg/kg) significantly increased the dark chamber entering time at intervals of 24 and 48 hours (p<0.001) and at concentrations of 100 and 200 mg/kg in all time periods after the shock (p<0.001).
Conclusion: Oral administrations of propolis can improve learning and memory dose-dependently in adult male mice. |
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Keywords: Propolis, Passive Avoidance Memory, Mice |
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Full-Text [PDF 139 kb]
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Type of Study: short communication |
Subject:
General Received: 2016/11/21 | Accepted: 2017/03/10 | Published: 2017/03/30
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