:: Volume 16, Issue 4 (winter 2016) ::
J Ardabil Univ Med Sci 2016, 16(4): 422-431 Back to browse issues page
Protective Effects of Enalapril on Reducing Sensorimotor Dysfunctions of Ischemic Stroke is enhanced by Its Combination with Alpha Tocopherol
Hamdollah Panahpour *, Adel Haghnejad Azar
Department of Physiology, School of medicine, Ardabil University of Medical Sciences, Ardabil, Iran
Abstract:   (6613 Views)

Background & objectives: Ischemic stroke has complex pathophysiology and its treatment with single neuroprotective drugs has so far failed. Combination therapy could produce amplified protective effects via different mechanisms. We examined the neuroprotective effects of enalapril and/or alpha tocopherol against sensorimotor dysfunctions of ischemic stroke.

Methods: Forty male Sprague-Dawley rats were randomly divided into five groups (n=8): sham, control ischemic, enalapril (0.03 mg/kg), alpha tocopherol (30mg/kg) and enalapril plus alpha tocopherol treated groups. Transient focal cerebral ischemia (90 min) was induced by occlusion of the left middle cerebral artery that followed by 24 h reperfusion periods. Infarct volumes were detected by TTC coloring technique and sensorimotor dysfunctions investigated by rotarod, grip strength and hotplate tests.

Results: Induction of cerebral ischemia in the control group produced severe neurological sensorimotor deficits in conjunction with considerable cerebral infarctions. Compared with the enalapril or alpha tocopherol groups, the combined treatment significantly improved neurological motor and sensory functions (p=0.038 and p=0.034, respectively) and also reduced the infarct volume (p=0.032).

Conclusion: Administration of alpha tocopherol increased protective effects of enalapril. Enalapril combined with alpha tocopherol can produce an augmented protection against ischemic brain injury, and improvement in sensorimotor dysfunctions.

Keywords: Stroke, Enalapril, Alpha Tocopherol, Rat
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Type of Study: article | Subject: General
Received: 2016/10/22 | Accepted: 2016/12/26 | Published: 2016/12/30

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