:: Volume 16, Issue 4 (winter 2016) ::
J Ardabil Univ Med Sci 2016, 16(4): 363-373 Back to browse issues page
Effect of Tanacetum parthenium Extract on Total Antioxidant Capacity of Tissues Damaged by Carbon Tetrachloride in Rats
Yavar Mahmoodzadeh , Mohammad Mazani * , Lotfollah Rezagholizadeh , Aliasghar Abbaspour , Eslam Zabihi , Pirooz Pourmohammad
Department of Biochemistry, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran , m.mazani@arums.ac.ir
Abstract:   (8610 Views)


Background & objectives: Some herbs contain compounds with antioxidant activity and can be used to protect or cure damages caused by chemical toxins. The aim of this study was to evaluate the effects of carbon tetrachloride (CCl4) on total antioxidants in various tissues and Tanacetum parthenium impacts on reducing devastating effects of carbon tetrachloride.

Methods: A total of 42 male Wistar rats were divided into seven groups of six animals in each group: normal control, damaged control, three groups that treated with 40, 80, and 120 mg/kg of Tanacetum parthenium extract 14 days before CCl4 injection and two groups served as post-treatment groups that received 80 and 120 mg/kg extract 2, 6, 24, and 48 h after CCl4 injection. At the end of study  the liver, kidney, testis, and heart were removed and then homogenized and then the antioxidant activity of the tissues assessed using FRAP method. Results were analyzed by one-way ANOVA test.

Results: The results showed that the injection of carbon tetrachloride significantly decreasestotal antioxidant in both liver (p<0.001) and kidney (p<0.05) tissues. Administration of extract significantly (p<0.05) increased the total antioxidant of liver and kidney.
Conclusion: Protective effect of Feverfew against CCl4 induced damages is more effective in liver and kidney than testis and heart..

Keywords: Total Antioxidant, Carbon Tetrachloride, Tanacetum Parthenium, Rat
Full-Text [PDF 315 kb]   (2786 Downloads)    
Type of Study: article | Subject: General
Received: 2016/10/22 | Accepted: 2016/12/30 | Published: 2016/12/30


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