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:: Volume 15, Issue 2 (summer 2015) ::
J Ardabil Univ Med Sci 2015, 15(2): 179-188 Back to browse issues page
Investigation of the Effect of Gold Nanoparticles on Vital Factors of Isolated Candida albicans in Patients with Vulvovaginal Candidiasis In Vitro
J Alipoor, M Madani , N Naghsh, M Bayat
Abstract:   (5126 Views)

  Background & objectives: In recent decades, nanotechnology has been developing in medical field, and most of the nanoparticles are highly valuable in hygienic care. Vulvovaginitis is an infectious disease giving rise to problem in genital tract and Candida albicans is the main cause of Vulvovaginitis.

  Methods: In this study, laboratory effect of gold nanoparticles has been investigated on Candida albicans isolates obtained from patients with Vulvovaginitis. Candida spp. isolates were obtained from 200 patients referring to medical diagnostic laboratory in Isfahan city during 2013, and identified using mycological methods including germ tube, clamydoconidia formation, and culturing on chrom agar media. Antifungal effect of gold nanoparticles was evaluated in concentration of 100, 50, 25, and 12.5 ppm on Candida isolates using well diffusion and microdilution methods. Fluconazole was used as a positive control and results were analyzed by SPSS15 software using Mann-Whitney, Kruskal-Wallis and average differences analysis tests.

  Results: The most averages of clear zone diameter for gold nanoparticle were 18, 15, 12 millimeter, respectively. Minimum inhibitory and fungicidal
concentration of gold nanoparticle was determined 6.25, 12.5 ppm and for fluconazole were 50.25±19.48 and 100.50±38.96, respectively. Based on obtained results antifungal activity of gold nanoparticle was dependent to concentration.

  Conclusion: In current study, inhibitory effect of gold nanoparticles was evaluated against microorganism. Although the laboratories findings are promising, more investigation should be conducted for therapeutic standardization.

Keywords: Gold Nanoparticles, Candida albicans, Vulvovaginal Candidiasis
Full-Text [PDF 488 kb]   (1371 Downloads)    
Type of Study: article |
Received: 2014/07/9 | Accepted: 2015/03/16 | Published: 2015/07/2
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Alipoor J, Madani M, Naghsh N, Bayat M. Investigation of the Effect of Gold Nanoparticles on Vital Factors of Isolated Candida albicans in Patients with Vulvovaginal Candidiasis In Vitro. J Ardabil Univ Med Sci. 2015; 15 (2) :179-188
URL: http://jarums.arums.ac.ir/article-1-854-en.html


Volume 15, Issue 2 (summer 2015) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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